Dysregulation of the Peripheral and Adipose Tissue Endocannabinoid System in Human Abdominal Obesity
| Autor: | Michael Stumvoll, Janin Berndt, Matthias Blüher, Mathias Fasshauer, Stefan Engeli, Pal Pacher, Michael R. Schön, Nora Klöting, Jens Jordan, Sandor Batkai |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Adipose tissue Arachidonic Acids Biology Article Amidohydrolases Body Mass Index Glycerides Receptor Cannabinoid CB1 Thinness Fatty acid amide hydrolase Internal medicine Diabetes mellitus Abdomen Cannabinoid Receptor Modulators Internal Medicine medicine Humans Insulin Obesity Abdominal obesity Sex Characteristics Body Weight Middle Aged Glucose clamp technique medicine.disease Endocannabinoid system Viscera Cholesterol Endocrinology Adipose Tissue Gene Expression Regulation Glucose Clamp Technique Female lipids (amino acids peptides and proteins) medicine.symptom Body mass index Endocannabinoids |
| Zdroj: | Diabetes. 55:3053-3060 |
| ISSN: | 1939-327X 0012-1797 |
| Popis: | The endocannabinoid system has been suspected to contribute to the association of visceral fat accumulation with metabolic diseases. We determined whether circulating endocannabinoids are related to visceral adipose tissue mass in lean, subcutaneous obese, and visceral obese subjects (10 men and 10 women in each group). We further measured expression of the cannabinoid type 1 (CB1) receptor and fatty acid amide hydrolase (FAAH) genes in paired samples of subcutaneous and visceral adipose tissue in all 60 subjects. Circulating 2-arachidonoyl glycerol (2-AG) was significantly correlated with body fat (r = 0.45, P = 0.03), visceral fat mass (r = 0.44, P = 0.003), and fasting plasma insulin concentrations (r = 0.41, P = 0.001) but negatively correlated to glucose infusion rate during clamp (r = 0.39, P = 0.009). In visceral adipose tissue, CB1 mRNA expression was negatively correlated with visceral fat mass (r = 0.32, P = 0.01), fasting insulin (r = 0.48, P < 0.001), and circulating 2-AG (r = 0.5, P < 0.001), whereas FAAH gene expression was negatively correlated with visceral fat mass (r = 0.39, P = 0.01) and circulating 2-AG (r = 0.77, P < 0.001). Our findings suggest that abdominal fat accumulation is a critical correlate of the dysregulation of the peripheral endocannabinoid system in human obesity. Thus, the endocannabinoid system may represent a primary target for the treatment of abdominal obesity and associated metabolic changes. |
| Databáze: | OpenAIRE |
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