Rnd family genes are differentially regulated by 3,4-methylenedioxymethamphetamine and cocaine acute treatment in mice brain

Autor: Alexandre David, Cynthia Marie-Claire, Cindie Courtin, Florence Noble, Corinne Canestrelli, Julie Salzmann
Přispěvatelé: Neuropsychopharmacologie des addictions. Vulnérabilité et variabilité expérimentale et clinique (NAVVEC - UM 81 (UMR 8206/ U705)), Université Paris Diderot - Paris 7 (UPD7)-Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Neuropsychopharmacologie des addictions. Vulnérabilité et variabilité expérimentale et clinique ( NAVVEC (UM 81) ), Université Paris Diderot - Paris 7 ( UPD7 ) -Institut des sciences du Médicament -Toxicologie - Chimie - Environnement ( IFR71 ), Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL ( ENSCP ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Ecole Nationale Supérieure de Chimie de Paris- Chimie ParisTech-PSL ( ENSCP ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Descartes - Paris 5 (UPD5)-Institut des sciences du Médicament -Toxicologie - Chimie - Environnement (IFR71), Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Ecole Nationale Supérieure de Chimie de Paris - Chimie ParisTech-PSL (ENSCP), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Université Paris Descartes - Paris 5 (UPD5)-Université Paris Diderot - Paris 7 (UPD7), Marie-Claire, Cynthia
Rok vydání: 2007
Předmět:
Male
rho GTP-Binding Proteins
MESH : RNA
Messenger
MESH : Cocaine
Time Factors
MESH: Dopamine Uptake Inhibitors
MESH : Brain Chemistry
Hippocampus
Striatum
Pharmacology
Mice
0302 clinical medicine
Cocaine
Dopamine Uptake Inhibitors
MESH: Up-Regulation
MESH: Animals
MESH: Brain Chemistry
Enzyme Inhibitors
Extracellular Signal-Regulated MAP Kinases
Prefrontal cortex
MESH : Up-Regulation
MESH: Extracellular Signal-Regulated MAP Kinases
MESH: Adrenergic Uptake Inhibitors
MESH : Adrenergic Uptake Inhibitors
0303 health sciences
MESH : Gene Expression Regulation
Adrenergic Uptake Inhibitors
General Neuroscience
Brain
MDMA
MESH : Extracellular Signal-Regulated MAP Kinases
MESH: Cocaine-Related Disorders
MESH: Gene Expression Regulation
Up-Regulation
3. Good health
medicine.anatomical_structure
[ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
MESH: Enzyme Inhibitors
[SDV.BBM.GTP] Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
medicine.symptom
MESH : Time Factors
medicine.drug
MESH : Male
N-Methyl-3
4-methylenedioxyamphetamine
Central nervous system
Biology
MESH : Cocaine-Related Disorders
MESH: Brain
Cocaine-Related Disorders
03 medical and health sciences
MESH: Cocaine
[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Genomics [q-bio.GN]
MESH : Mice
MESH : rho GTP-Binding Proteins
medicine
Animals
RNA
Messenger
MESH : N-Methyl-3
4-methylenedioxyamphetamine
MESH: Mice
Molecular Biology
MESH: RNA
Messenger
030304 developmental biology
Brain Chemistry
MESH : Enzyme Inhibitors
Rnd3
MESH: Time Factors
MESH: rho GTP-Binding Proteins
Actin cytoskeleton
MESH: Male
MESH : Brain
Gene Expression Regulation
Mechanism of action
MESH: N-Methyl-3
4-methylenedioxyamphetamine
MESH : Animals
Neurology (clinical)
MESH : Dopamine Uptake Inhibitors
030217 neurology & neurosurgery
Developmental Biology
Zdroj: Brain Research
Brain Research, 2007, 1134 (1), pp.12-7. ⟨10.1016/j.brainres.2006.11.065⟩
Brain Research, Elsevier, 2007, 1134 (1), pp.12-7. 〈10.1016/j.brainres.2006.11.065〉
Brain Research, Elsevier, 2007, 1134 (1), pp.12-7. ⟨10.1016/j.brainres.2006.11.065⟩
ISSN: 0006-8993
Popis: International audience; Drugs of abuse induce alterations in cytoskeletal and cytoskeleton associated genes in several brain areas. We have previously shown that acute MDMA regulates the mRNA level of Rnd3, a Rho GTPase involved in actin cytoskeleton regulation, in mice striatum. In this study we investigated the effects of single administration of cocaine, another psychostimulant with a slightly different mechanism of action, on the mRNA levels of the three members of the Rnd genes family (Rnd1, Rnd2 and Rnd3). Mice were treated with either MDMA (9 mg/kg) or cocaine (20 mg/jg) and brain samples (i.e. hippocampus, striatum and prefrontal cortex) were processed for quantitative real-time PCR assay 1, 2, 4 and 6 h after the injections. The expression level of Rnd2 was differentially affected depending on the drug, brain area and time point after injection. Interestingly the two drugs up-regulate Rnd3 gene expression in the three structures tested with some differences in the timing. The effects of MDMA on Rnd3 appear earlier in the hippocampus as compared to cocaine, while it is the opposite in the prefrontal cortex. However, in the dorsal striatum, the two drugs induce an early and significant up-regulation of Rnd3 expression that is longer-lasting in the case of MDMA. In the case of cocaine contrarily to what was observed with MDMA, this modulation could not be blocked with the ERK activation inhibitor SL327 suggesting that the two drugs lead to the same effect on Rnd3 by two distinct pathways.
Databáze: OpenAIRE
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