No effects of PRP on ultrasonographic tendon structure and neovascularisation in chronic midportion Achilles tendinopathy
| Autor: | Johannes L. Tol, H. T. M. van Schie, Harrie Weinans, Adam Weir, R J de Vos, Jan A N Verhaar |
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| Přispěvatelé: | Other departments, Orthopedics and Sports Medicine |
| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Physical Therapy Sports Therapy and Rehabilitation Tendon structure Achilles Tendon Achilles tendinitis law.invention Young Adult Double-Blind Method Randomized controlled trial law medicine Humans Orthopedics and Sports Medicine Treatment Failure Ultrasonography Doppler Color Aged Neovascularization Pathologic Platelet-Rich Plasma business.industry General Medicine Middle Aged medicine.disease Medical department Exercise Therapy Surgery Clinical trial Platelet-rich plasma Chronic Disease Tendinopathy Female Ultrasonography business Sports |
| Zdroj: | British journal of sports medicine, 45(5), 387-392. BMJ Publishing Group British Journal of Sports Medicine, 45(5), 387-392. BMJ Publishing Group |
| ISSN: | 0306-3674 |
| Popis: | Objective To assess whether a platelet-rich plasma (PRP) injection leads to an enhanced tendon structure and neovascularisation, measured with ultrasonographic techniques, in chronic midportion Achilles tendinopathy. Design Double-blind, randomised, placebo-controlled clinical trial. Setting Sports medical department of The Hague medical centre. Patients 54 patients with chronic midportion Achilles tendinopathy were included. Interventions Patients were randomised to eccentric exercise therapy with either a PRP injection (PRP group) or a saline injection (placebo group). Main outcome measurements Tendon structure was evaluated by ultrasonographic tissue characterisation, a novel technique which quantifies tendon structure into four echo-types: echo-types I+II represent organised tendon bundles, whereas echo-types III+IV represent a disorganised tendon structure. Colour Doppler ultrasonography was used to measure the degree of neovascularisation. Follow-up was at 6, 12 and 24 weeks. Results A significant improvement in echo-types I+II was found after 24 weeks within both the PRP group (n=27) and the placebo group (n=27), but there was no signifi cant between-group difference (95% Cl - 1.6 to 7.8, p=0.169). After 6 weeks, the neovascularisation score increased within the PRP group (p=0.001) and the placebo group (p=0.002), but there was no signifi cant between-group difference in change in neovascularisation score at any point in time. Conclusion Injecting PRP for the treatment of chronic midportion Achilles tendinopathy does not contribute to an increased tendon structure or alter the degree of neovascularisation, compared with placebo. |
| Databáze: | OpenAIRE |
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