Serum interleukin-6: Association with circulating cytokine serum levels in patients with sinus arrhythmia and patients with coronary artery disease
| Autor: | Emilija Antova, Irina Lovchikova, Alexander Zotov, A.A. Aksyonov, Mitko Mladenov, A. L. Shim, Andre Kamkin, R.S. Ovchinnikov, V.M. Mitrokhin, A.V. Konev, M.A. Konoplyannikov |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Immunology Coronary Artery Disease 030204 cardiovascular system & hematology Diagnosis Differential Coronary artery disease 03 medical and health sciences 0302 clinical medicine Diabetes mellitus Internal medicine medicine Humans Arrhythmia Sinus Prospective Studies Interleukin 6 Sinus (anatomy) Aged Asthma Ejection fraction biology Interleukin-6 business.industry Sleep apnea Middle Aged medicine.disease Institutional review board 030104 developmental biology medicine.anatomical_structure Cardiology biology.protein Cytokines Female business Biomarkers |
| Zdroj: | Cellular Immunology. 310:178-183 |
| ISSN: | 0008-8749 |
| Popis: | In this study, we were focused on the differences between certain circulating cytokine levels in patients with or without sinus arrhythmia, according to the median IL-6 level. All patients were stable with regards to symptoms and therapy for at least one month prior to the measurements conducted within this study. Exclusion criteria were: patients with sleep apnea, asthma, respiratory insufficiency of any genesis, active infection, allergy, inflammatory diseases, cancer, diabetes of any type and treatment with anti-inflammatory drugs. The study was approved by the Institutional Review Board. All recruited patients gave their verbal and written consent for participation in the study. The study group consisted of 74 patients divided into two groups: with (38) and without sinus arrhythmia but with diagnosed coronary artery disease (36). Sinus arrhythmia was confirmed by 24 h Holter monitoring. From all test parameters only cytokines IL-2, IL-8, IL-10, IL-17 and IL-18, showed statistically significant increasing in patients with statistically higher IL-6 levels. It is possible that IL-6 may not be a marker for the selection of patients with sinus arrhythmia or coronary artery disease. The findings indicate that IL-6 represents a reliable indicator for increased expression of IL-2, IL-8, IL-10, IL-17 and IL-18 in patients with sinus arrhythmia or coronary artery disease. Further studies in a large number of patients would be necessary to confirm our observations. |
| Databáze: | OpenAIRE |
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