Enhanced site-selectivity in acylation reactions with substrate-optimized catalysts on solid supports
| Autor: | Florian Huber, Estelle S. Taghuo Kaptouom, My Linh Tong, Torsten Cellnik, Stefan F. Kirsch |
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| Rok vydání: | 2017 |
| Předmět: |
inorganic chemicals
010405 organic chemistry Chemistry Site selectivity Metals and Alloys Substrate (chemistry) Nanotechnology General Chemistry 010402 general chemistry 01 natural sciences Small molecule Combinatorial chemistry Catalysis 0104 chemical sciences Surfaces Coatings and Films Electronic Optical and Magnetic Materials Acylation Phase (matter) Materials Chemistry Ceramics and Composites Site selective |
| Zdroj: | Chemical communications (Cambridge, England). 53(21) |
| ISSN: | 1364-548X |
| Popis: | A concept for site selective acylation of poly-hydroxylated substrates is presented where polymer-supported catalysts are employed: catalytically active DMAP units were combined with a library of small molecule peptides attached to the solid phase with the goal to identify substrate-optimized catalysts through library screening. For selected examples, we demonstrate how the optimized catalysts can convert “their” substrate with a markedly enhanced site-selectivity, compared to only DMAP. Due to the solid support, product purification is significantly simplified, and the peptidic catalysts can be easily reused in multiple cycles while conserving its efficiency. |
| Databáze: | OpenAIRE |
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