Randomized comparison of reduced fat and reduced carbohydrate hypocaloric diets on intrahepatic fat in overweight and obese human subjects
| Autor: | Henrike Sell, Wolfgang Utz, Jens Jordan, Mario Hermsdorf, Anja Mähler, Verena Haas, Jeanette Schulz-Menger, Michael Boschmann, Friedrich C. Luft, Sven Haufe, Petra Kast, Juergen Eckel, Stefan Engeli, Jana Böhnke, Heidrun Mehling, Christoph Otto, Andreas L. Birkenfeld, Susanne Wiesner |
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| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Overweight Diet Carbohydrate-Restricted Internal medicine Reduced fat medicine Humans Obesity Prospective Studies Risk factor Prospective cohort study Diet Fat-Restricted Caloric Restriction Hepatology business.industry Carbohydrate Middle Aged medicine.disease Fatty Liver Endocrinology Female Steatosis medicine.symptom business |
| Zdroj: | Hepatology (Baltimore, Md.). 53(5) |
| ISSN: | 1527-3350 |
| Popis: | Obesity-related hepatic steatosis is a major risk factor for metabolic and cardiovascular disease. Fat reduced hypocaloric diets are able to relieve the liver from ectopically stored lipids. We hypothesized that the widely used low carbohydrate hypocaloric diets are similarly effective in this regard. A total of 170 overweight and obese, otherwise healthy subjects were randomized to either reduced carbohydrate (n = 84) or reduced fat (n = 86), total energy restricted diet (−30% of energy intake before diet) for 6 months. Body composition was estimated by bioimpedance analyses and abdominal fat distribution by magnetic resonance tomography. Subjects were also submitted to fat spectroscopy of liver and oral glucose tolerance testing. In all, 102 subjects completed the diet intervention with measurements of intrahepatic lipid content. Both hypocaloric diets decreased body weight, total body fat, visceral fat, and intrahepatic lipid content. Subjects with high baseline intrahepatic lipids (>5.56%) lost ≈7-fold more intrahepatic lipids compared with those with low baseline values ( |
| Databáze: | OpenAIRE |
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