A possible covalent xanthine oxidase inhibitor TS10: Inhibition mechanism, metabolites identification and PDPK assessment

Autor:	Ting-jian Zhang, Xu Zhang, En-yu Xu, Zhao-ran Wang, Zhen-hao Zhang, Qiu-yin Wang, Lin Wang, Yan-qing Wen, Fan-hao Meng
Rok vydání:	2022
Předmět:	Molecular Docking Simulation Xanthine Oxidase Allopurinol Organic Chemistry Drug Discovery Enzyme Inhibitors Molecular Biology Biochemistry Uric Acid
Zdroj:	Bioorganic Chemistry. 128:106064
ISSN:	0045-2068
Popis:	Xanthine oxidase (XO) inhibitors are widely used in the control of serum uric acid levels in the clinical management of gout. Our continuous efforts in searching novel amide-based XO inhibitors culminated in the identification of N-(4-((3-cyanobenzyl)oxy)-3-(1H-tetrazol-1-yl)phenyl)isonicotinamide (TS10), which exhibited comparable in vitro inhibition to that of topiroxostat (TS10, IC
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31fbd1553bb5974a6a5436f33879a9b7 https://doi.org/10.1016/j.bioorg.2022.106064 Zobrazit plný text záznamu Full Text from ScienceDirect