Use of i.m. ranitidine for the prophylaxis of aspiration pneumonitis in obstetrics
| Autor: | B. A. Loughnan, R. D. Colman, R.W. Cattermole, D. G. Cohen, M. Frank |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
Adult
medicine.medical_specialty Aspiration pneumonia Aspiration Pneumonitis Anesthesia General Pneumonia Aspiration Ranitidine Injections Intramuscular Citric Acid chemistry.chemical_compound Pregnancy Sodium citrate Elective Cesarean Delivery medicine Anesthesia Obstetrical Humans Citrates business.industry Cesarean Section Gastric Acidity Determination medicine.disease Gastric ph Surgery Anesthesiology and Pain Medicine Pulmonary aspiration chemistry Anesthesia Female Antacids Elective caesarean section business Preanesthetic Medication medicine.drug |
| Zdroj: | British journal of anaesthesia. 61(6) |
| ISSN: | 0007-0912 |
| Popis: | Twenty patients who underwent elective Caesarean section received ranitidine 150 mg by mouth 8-14 h, and 50 mg i.m. 90 min, before surgery. Intraoperative gastric aspiration resulted in contents with a pH greater than 2.5 and volume less than 25 ml in all patients (mean pH 6.5 (SD 0.8); mean volume 9.0 (SD 7.2) ml). Sixty patients in labour, who received ranitidine 50 mg i.m. 6-hourly, underwent emergency surgery. Half of this group received, in addition, a single preinduction dose of either 15 or 30 ml of sodium citrate 0.3 mol litre-1. A further 30 patients who remained unmedicated during labour and required emergency surgery received a preinduction dose of 15 or 30 ml of sodium citrate 0.3 mol litre-1 alone. Ranitidine medication resulted in a mean aspirated gastric volume of 31.4 (26.6) ml and pH of 5.3 (2.1); five of 30 patients had a pH less than 2.5. The addition of sodium citrate 0.3 mol litre-1 resulted in gastric pH greater than 2.5 in all patients and a mean gastric volume of 43.2 (38.3) ml. The group who received only sodium citrate 0.3 mol litre-1 had a mean pH of 5.3 (1.1) and a mean volume 122.7 (98.2) ml. |
| Databáze: | OpenAIRE |
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