Synthesis and Biological activity of kappa opioid receptor agonists. Part 2: Preparation of 3-aryl-2-pyridone analogues generated by solution- and solid-phase parallel synthesis methods

Autor:	Lars Swanson, Magnus Johansson, Asa Rosenquist, Graeme Semple, Jennie Georgsson, Vijay Chhajlani, Britt Marie Andersson
Rok vydání:	2003
Předmět:	Alkylation Chemical Phenomena Pyridones Clinical Biochemistry Receptors Opioid mu Pharmaceutical Science Biochemistry κ-opioid receptor Chemical synthesis 2-Pyridone Structure-Activity Relationship chemistry.chemical_compound Peptide Library Receptors Opioid delta Opioid Receptor Binding Drug Discovery Structure–activity relationship Molecular Biology Chemistry Physical Chemistry Receptors Opioid kappa Aryl Organic Chemistry Biological activity Combinatorial chemistry Solutions Lactam Molecular Medicine Indicators and Reagents
Zdroj:	Bioorganic & Medicinal Chemistry Letters. 13:1141-1145
ISSN:	0960-894X
DOI:	10.1016/s0960-894x(03)00033-7
Popis:	New analogues of the previously described 3-aryl pyridone KOR agonists have been synthesised by parallel synthetic methods, both in solution- and with solid-phase chemistry, making use of the well known and versatile Mitsunobu, Suzuki and Buchwald reactions. Opioid receptor binding data for the compounds produced is reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31f889c28d9b12c9e4627062519700fd https://doi.org/10.1016/s0960-894x(03)00033-7 Zobrazit plný text záznamu Full Text from ScienceDirect