Profile and Management of Toxicity of Selinexor and Belantamab Mafodotin for the Treatment of Triple Class Refractory Multiple Myeloma
Autor: | Saman Bahram, Ahsan Wahab, Tehniat Faraz, Hamid Ehsan, Adeel Masood, Abdul Hannan, Karun Neupane, Faiz Anwer |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
Oncology
safety medicine.medical_specialty hematological malignancy treatment Anemia Constitutional symptoms business.industry Refractory Multiple Myeloma Hematology Disease Review medicine.disease Internal medicine relapsed and refractory multiple myeloma Toxicity medicine In patient Hyponatremia business Multiple myeloma ocular toxicity |
Zdroj: | Journal of Blood Medicine |
ISSN: | 1179-2736 |
Popis: | Treatment options are limited for multiple myeloma patients who have developed four/five drug-refractory disease. Selinexor (Sel) and belantamab mafodotin (belamaf) were recently approved by the US FDA for treatment of RRMM. The toxicity profile of these drugs is a concern since these agents are used in patients who have already undergone multiple lines of treatment. In this review, we discuss the toxicity profile and strategies for the management of toxicities of Sel and belamaf for the treatment of RRMM. We conducted a comprehensive literature search on PubMed, Embase, Cochrane, and Clinicaltrials.gov using the terms “selinexor”, “belantamab”, “belamaf”, and “multiple myeloma” without applying any limitations based on the date of the study, language, or country of origin. The most common hematological toxicity associated with these two drugs is thrombocytopenia. Cytopenias, constitutional symptoms, gastrointestinal effects, and hyponatremia are the major toxicities of Sel. Keratopathy and anemia are the major toxicities of belamaf. Treatment modifications and dose interruption are usually needed when side effects are more than grade II. As these are newer drugs with limited data, continuous surveillance and monitoring are warranted during the treatment course with early mitigation strategies. |
Databáze: | OpenAIRE |
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