Genetic Risk of Arrhythmic Phenotypes in Patients With Dilated Cardiomyopathy
| Autor: | Dobromir Slavov, William J. McKenna, Marco Merlo, Marta Gigli, Matthew R.G. Taylor, Francesca Brun, Teisha J. Rowland, Gianfranco Sinagra, Giulia Barbati, Andrea Cocciolo, Sharon L. Graw, Mary E. Haywood, Davide Stolfo, Francisco G. La Rosa, Gaetano Morea, Alessandro Altinier, Federica Ramani, Matteo Dal Ferro, Ilaria Puggia, Luisa Mestroni |
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| Přispěvatelé: | Merlo, M., Gigli, M., Graw, S. L., Barbati, G., Rowland, T. J., Slavov, D. B., Stolfo, D., Haywood, M. E., Dal Ferro, M., Altinier, A., Ramani, F., Brun, F., Cocciolo, A., Puggia, I., Morea, G., Mckenna, W. J., La Rosa, F. G., Taylor, M. R. G., Sinagra, G., Mestroni, L. |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
desmosomal mutations medicine.medical_treatment genotype-phenotype correlation 030204 cardiovascular system & hematology dilated cardiomyopathy prognosis Sudden cardiac death LMNA 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine cardiovascular diseases 030212 general & internal medicine Heart transplantation Ejection fraction business.industry Dilated cardiomyopathy medicine.disease Phenotype desmosomal mutation Ventricular assist device Ventricular fibrillation cardiovascular system Cardiology Cardiology and Cardiovascular Medicine business |
| Zdroj: | Journal of the American College of Cardiology. 74:1480-1490 |
| ISSN: | 0735-1097 |
| Popis: | Background Genotype-phenotype correlations in dilated cardiomyopathy (DCM) and, in particular, the effects of gene variants on clinical outcomes remain poorly understood. Objectives The purpose of this study was to investigate the prognostic role of genetic variant carrier status in a large cohort of DCM patients. Methods A total of 487 DCM patients were analyzed by next-generation sequencing and categorized the disease genes into functional gene groups. The following composite outcome measures were assessed: 1) all-cause mortality; 2) heart failure–related death, heart transplantation, or destination left ventricular assist device implantation (DHF/HTx/VAD); and 3) sudden cardiac death/sustained ventricular tachycardia/ventricular fibrillation (SCD/VT/VF). Results A total of 183 pathogenic/likely pathogenic variants were found in 178 patients (37%): 54 (11%) Titin; 19 (4%) Lamin A/C (LMNA); 24 (5%) structural cytoskeleton-Z disk genes; 16 (3.5%) desmosomal genes; 46 (9.5%) sarcomeric genes; 8 (1.6%) ion channel genes; and 11 (2.5%) other genes. All-cause mortality was no different between variant carriers and noncarriers (p = 0.99). A trend toward worse SCD/VT/VF (p = 0.062) and DHF/HTx/VAD (p = 0.061) was found in carriers. Carriers of desmosomal and LMNA variants experienced the highest rate of SCD/VT/VF, which was independent of the left ventricular ejection fraction. Conclusions Desmosomal and LMNA gene variants identify the subset of DCM patients who are at greatest risk for SCD and life-threatening ventricular arrhythmias, regardless of the left ventricular ejection fraction. |
| Databáze: | OpenAIRE |
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