To Push or To Pull? In a Post-COVID World, Supporting and Incentivizing Antimicrobial Drug Development Must Become a Governmental Priority
| Autor: | R. Leszczynski, Ayako Ebata, Jehangir Cama, A. Khalid, V. Lok, Christopher G. Dowson, P. K. Tang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
RM 030106 microbiology Context (language use) 03 medical and health sciences World economy access Drug Development global health policy push and pull incentives Development economics Pandemic Drug Resistance Bacterial Global health Humans market failure antimicrobial resistance One Health Pandemics Market failure 2. Zero hunger Motivation SARS-CoV-2 COVID-19 QR 3. Good health Anti-Bacterial Agents 030104 developmental biology Infectious Diseases Incentive Drug development Government Perspective Business RB |
| Zdroj: | ACS Infectious Diseases |
| ISSN: | 2373-8227 |
| Popis: | The COVID-19 pandemic has refocused attention worldwide on the dangers of infectious diseases, in terms of both global health and the effects on the world economy. Even in high income countries, health systems have been found wanting in dealing with the new infectious agent. However, the even greater long-term danger of antimicrobial resistance in pathogenic bacteria and fungi is still under-appreciated, especially among the general public. Although antimicrobial drug development faces significant scientific challenges, the gravest challenge at the moment appears to be economic, where the lack of a viable market has led to a collapse in drug development pipelines. There is therefore a critical need for governments across the world to further incentivize the development of antimicrobials. Most incentive strategies over the past decade have focused on so-called “push” incentives that bridge the costs of antimicrobial research and development, but these have been insufficient for reviving the pipeline. In this Perspective, we analyze the current incentive strategies in place for antimicrobial drug development, and focus on “pull” incentives, which instead aim to improve revenue generation and thereby resolve the antimicrobial market failure challenge. We further analyze these incentives in a broader “One Health” context and stress the importance of developing and enforcing strict protocols to ensure appropriate manufacturing practices and responsible use. Our analysis reiterates the importance of international cooperation, coordination across antimicrobial research, and sustained funding in tackling this significant global challenge. A failure to invest wisely and continuously to incentivize antimicrobial pipelines will have catastrophic consequences for global health and wellbeing in the years to come.\ud \ud |
| Databáze: | OpenAIRE |
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