Microwave focal therapy of prostate cancer: a non‐clinical study and exploratory clinical trial

Autor: Hidehisa Boku, Masatomo Kaneko, Yasuhiro Yamada, Yukiko Morinaga, Eiichi Konishi, Aoi Uno, Toshiko Ito‐Ihara, Ayumu Yamada, Go Horiguchi, Satoshi Teramukai, Atsuko Fujihara, Takumi Shiraishi, Takeshi Yamada, Takashi Ueda, Toru Matsugasumi, Munehiro Ohashi, Daisuke Horiuchi, Yuta Inoue, Osamu Ukimura
Rok vydání: 2022
Předmět:
Zdroj: BJU International. 130:776-785
ISSN: 1464-410X
1464-4096
Popis: To examine the safety and efficacy of microwave tissue coagulation (MTC) for prostate cancer and assess its use in lesion-targeted focal therapy in a non-clinical study and a clinical phase II trial.In the non-clinical study using MicrotazeThe region of coagulative necrosis was predictable by monitoring of ultrasonically visible vaporization; thus, by placing the MTC needle at a certain distance, we were able to perform a safe procedure without adverse events affecting the surrounding organs. Based on the non-clinical study, which used various combinations of output and irradiation time, MTC with 30-W output for 60-s irradiation was selected for the prostate. Based on the predictable necrosis, the therapeutic plan (where to place the MTC needle to achieve complete ablation of the target and how many sessions) was strictly determined per patient. There were no serious adverse events in any patient and only temporary urinary symptoms related to MTC therapy were observed. Furthermore, post-treatment satisfaction was very high. All preoperative MRI-visible lesions disappeared, and PSA decreased by 55% 6 months after surgery.Microwave tissue coagulation may be an option for lesion-targeted focal therapy for prostate cancer.
Databáze: OpenAIRE
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