Lack of genomic rearrangements involving the aromatase gene CYP19A1 in breast cancer
| Autor: | Shinzaburo Noguchi, Kazuhiko Nakabayashi, Makio Shozu, Tsutomu Ogata, Junichi Suzuki, Ryo Tsunashima, Maki Fukami |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
endocrine system Breast Neoplasms Transactivation Aromatase Breast cancer Gene duplication medicine Humans Pharmacology (medical) Radiology Nuclear Medicine and imaging Promoter Regions Genetic Aged Aged 80 and over Gene Rearrangement Chromosomes Human Pair 15 Comparative Genomic Hybridization biology Aromatase excess syndrome General Medicine Gene rearrangement Middle Aged medicine.disease Molecular biology Gene Expression Regulation Neoplastic genomic DNA Oncology biology.protein Cancer research Female Comparative genomic hybridization |
| Zdroj: | Breast Cancer. 21:382-385 |
| ISSN: | 1880-4233 1340-6868 |
| Popis: | Increased intratumoral expression of aromatase, the key enzyme for estrogen biosynthesis, is predicted to be of critical importance in the development of breast cancer. Recently, several germline rearrangements at 15q21 have been shown to cause overexpression of the aromatase gene CYP19A1 and resulting aromatase excess syndrome. To determine whether submicroscopic genomic rearrangements at 15q21 are involved in aromatase overexpression in breast cancer tissues, we investigated copy-number alterations in genomic DNA obtained from 44 tumor samples. Comparative genomic hybridization analysis identified no deletion or duplication at 15q21 in the 44 samples. These results, in conjunction with previous data, indicate that aromatase overexpression in breast cancer tissues is likely to result from a promoter switch of CYP19A1 and/or accumulation of CYP19A1-expressing cells, rather than from cryptic transactivation of CYP19A1 because of genomic rearrangements at 15q21. |
| Databáze: | OpenAIRE |
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