Is still there a place for orteronel in management of prostate cancer? Data from a literature based meta-analysis of randomized trials
| Autor: | Chiara Pacifico, Giovanni Chiriacò, Giandomenico Roviello, Daniele Generali |
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| Přispěvatelé: | Roviello, Giandomenico, Pacifico, Chiara, Chiriacò, Giovanni, Generali, Daniele |
| Rok vydání: | 2017 |
| Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Efficacy Survival Antineoplastic Agents Orteronel PSA Prostate carcinoma Disease Naphthalenes Placebo Disease-Free Survival law.invention Management of prostate cancer 03 medical and health sciences chemistry.chemical_compound Prostate cancer 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Humans Progression-free survival Randomized Controlled Trials as Topic business.industry Imidazoles Prostatic Neoplasms Steroid 17-alpha-Hydroxylase Hematology Prostate-Specific Antigen medicine.disease 030104 developmental biology chemistry 030220 oncology & carcinogenesis Meta-analysis business |
| Zdroj: | Critical Reviews in Oncology/Hematology. 113:18-21 |
| ISSN: | 1040-8428 |
| DOI: | 10.1016/j.critrevonc.2017.02.023 |
| Popis: | Orteronel (TAK-700) is an oral, non-steroidal 17,20-lyase inhibitor with higher specificity for 17,20 lyase over 17 hydroxylase. The first phase III studies showed an advantage with orteronel compared with placebo in terms of progression free survival and response of PSA. Unfortunately orteronel did not significantly prolong the overall survival. In order to assess the efficacy of orteronel in prostate cancer, we evaluated all available data on orteronel in the management of prostate cancer. A total of 2716 patients were evaluated from 3 randomized trials. We showed orteronel improved the progression free survival, time to PSA progression and PSA response compared with the placebo. In conclusion, given the limitations a literature rather than on individual patients' data meta-analysis, our data show a clinical efficacy of orteronel in prostate cancer, therefore we deem that orteronel may be investigated in combination with the other approved agents for CRPC or be tested in prior setting of disease such as the hormone sensitive prostate cancer. |
| Databáze: | OpenAIRE |
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