Prenatal stress alters circadian activity of hypothalamo-pituitary-adrenal axis and hippocampal corticosteroid receptors in adult rats of both gender

Autor: Josette Dulluc, Muriel Koehl, Stefania Maccari, Michel Le Moal, Muriel Darnaudéry, Olivier Van Reeth
Přispěvatelé: Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale (U1215 Inserm - UB), Université de Bordeaux (UB)-Institut François Magendie-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Biologie du Développement de Marseille (IBDM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), INSERM, Neurocentre Magendie, U1215, Physiopathologie de la Plasticité Neuronale, F-33000 Bordeaux, France, Koehl, Muriel
Rok vydání: 1999
Předmět:
Male
Receptors
Steroid
MESH: Hippocampus
Pituitary-Adrenal System
MESH: Rats
Sprague-Dawley
Hippocampal formation
Hippocampus
Rats
Sprague-Dawley
chemistry.chemical_compound
MESH: Pregnancy
Pregnancy
Corticosterone
Homeostasis
MESH: Animals
Receptor
General Neuroscience
MESH: Stress
Psychological
Circadian Rhythm
MESH: Homeostasis
MESH: Pituitary-Adrenal System
Prenatal Exposure Delayed Effects
Corticosteroid
Female
[SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Hypothalamo-Hypophyseal System
medicine.medical_specialty
MESH: Rats
medicine.drug_class
Period (gene)
Biology
MESH: Hypothalamo-Hypophyseal System
MESH: Prenatal Exposure Delayed Effects
Cellular and Molecular Neuroscience
Sex Factors
Adrenocorticotropic Hormone
MESH: Sex Factors
Internal medicine
medicine
Animals
[SDV.NEU] Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
MESH: Circadian Rhythm
Circadian rhythm
MESH: Adrenocorticotropic Hormone
MESH: Male
Rats
Endocrinology
chemistry
Prenatal stress
MESH: Corticosterone
MESH: Female
Stress
Psychological
MESH: Receptors
Steroid
Zdroj: Journal of Neurobiology
Journal of Neurobiology, 1999, 40 (3), pp.302-15
Journal of Neurobiology, Wiley, 1999, 40 (3), pp.302-15
ISSN: 1097-4695
0022-3034
DOI: 10.1002/(sici)1097-4695(19990905)40:3<302::aid-neu3>3.0.co;2-7
Popis: International audience; Prenatal stress impairs activity of the hypothalamo-pituitary-adrenal (HPA) axis in response to stress in adult offspring. So far, very few data are available on the effects of prenatal stress on circadian functioning of the HPA axis. Here, we studied the effects of prenatal stress on the circadian rhythm of corticosterone secretion in male and female adult rats. To evaluate the effects of prenatal stress on various regulatory components of corticosterone secretion, we also assessed the diurnal fluctuation of adrenocorticotropin, total and free corticosterone levels, and hippocampal corticosteroid receptors. Finally, in the search of possible maternal factors, we studied the effects of repeated restraint stress on the pattern of corticosterone secretion in pregnant female rats. Results demonstrate that prenatal stress induced higher levels of total and free corticosterone secretion at the end of the light period in both males and females, and hypercorticism over the entire diurnal cycle in females. No diurnal fluctuation of adrenocorticotropin was observed in any group studied. The effects of prenatal stress on corticosterone secretion could be mediated, at least in part, by a reduction in corticosteroid receptors at specific times of day. Results also show that prepartal stress alters the pattern of corticosterone secretion in pregnant females. Those data indicate that prenatally stressed rats exhibit an altered temporal functioning of the HPA axis, which, taken together with their abnormal response to stress, reinforces the idea of a general homeostatic dysfunction in those animals.
Databáze: OpenAIRE
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