Local benefit of prostaglandin E2 in radiochemotherapy-induced oral mucositis
| Autor: | A Schein, M. Matejka, Helmut Sinzinger, H. Porteder, A. Nell, Kment G, G. Mailath, M. Leukauf |
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| Rok vydání: | 1990 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Metabolite Gastroenterology Dinoprostone chemistry.chemical_compound Internal medicine medicine Mucositis Humans Prostaglandin E2 Stomatitis Aged Chemotherapy Analysis of Variance Radiotherapy business.industry Mouth Mucosa Cancer Middle Aged medicine.disease Radiation therapy Otorhinolaryngology chemistry Head and Neck Neoplasms Anesthesia Toxicity lipids (amino acids peptides and proteins) Surgery Female Oral Surgery business medicine.drug |
| Zdroj: | The British journal of oralmaxillofacial surgery. 28(2) |
| ISSN: | 0266-4356 |
| Popis: | In 15 patients suffering from maxillofacial cancer with radiochemotherapy-induced oral mucositis the local application of prostaglandin E2 (PGE2) tablets, 0.5 mg four times a day at a 4-h interval was performed. Plasma determination of the bicyclo-prostaglandin E2 metabolite showed no significant amount of the locally applied substance in the circulation. It is claimed that for this particular indication, PGE2 is a potent locally acting compound without affecting circulating levels. |
| Databáze: | OpenAIRE |
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