| Popis: |
The study aimed to assess chemical composition and pharmacological properties ofRosa x gallicacultivated in Georgia for application in medicine and cosmetology. The quantitative and qualitative composition of secondary metabolites of the aqueous extract obtained during the production of essential oil ofR. gallica(AERGP) was analysed using HPLC analytical methods, and its pharmacological activity was evaluated inin vitroandin vivoexperiments. Five prevalent compounds have been established in AERGP: Glycyrrhetinic acid (0.83%), Hyperoside (1, 08%), Caffeic acid (0, 85%), Quercetin (6, 17%), and Ferulic acid (0, 28%). Studies of antioxidant activity of AERGP revealed its dose-dependent radical scavenging effect in both ABTS (IC5020.0 µg/mL), and DPPH (IC5039.0 µg/mL) assays. AERGP appeared active againstPlasmodium falciparum3D7 strain (IC5047.2 µg/mL). Inin vivoexperiments AERGP showed pronounced analgesic (124%) and anti-inflammatory effects (67.58%), as well as a moderate gastroprotective efficacy (28, 9%). |
