Extracellular AGR3 regulates breast cancer cells migration via Src signaling
| Autor: | Silvia Pastorekova, Joanna Obacz, Daria Sicari, Michal Durech, Frédéric Delom, Lucia Sommerova, Filippo Iuliano, Eric Chevet, Delphine Fessart, Tony Avril, Roman Hrstka |
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| Přispěvatelé: | Chemistry, Oncogenesis, Stress and Signaling (COSS), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Masaryk Memorial Cancer Institute (RECAMO), Slovak Academy of Sciences (SAS), CRLCC Eugène Marquis (CRLCC), Actions for OnCogenesis understanding and Target Identification in ONcology (ACTION), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Bordeaux Segalen - Bordeaux 2-Institut Bergonié [Bordeaux], UNICANCER-UNICANCER, Institut Bergonié [Bordeaux], UNICANCER, Université de Rennes (UR)-CRLCC Eugène Marquis (CRLCC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Masaryk Memorial Cancer Institute (MMCI), UNICANCER-UNICANCER-Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Jonchère, Laurent |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research medicine.drug_class AGR2 [SDV.CAN]Life Sciences [q-bio]/Cancer Src family kinases migration 03 medical and health sciences Src phosphorylation 0302 clinical medicine [SDV.CAN] Life Sciences [q-bio]/Cancer Extracellular medicine cancer anterior gradient proteins Oncogene Chemistry Kinase Articles Protein kinase inhibitor Cell cycle Dasatinib adhesion 030104 developmental biology Oncology 030220 oncology & carcinogenesis Cancer research secreted protein disulfide isomerase family medicine.drug Proto-oncogene tyrosine-protein kinase Src |
| Zdroj: | Oncology Letters Oncology Letters, Spandidos Publications, 2019, 18 (5), pp.4449-4456. ⟨10.3892/ol.2019.10849⟩ Oncology Letters, 2019, 18 (5), pp.4449-4456. ⟨10.3892/ol.2019.10849⟩ |
| ISSN: | 1792-1074 1792-1082 |
| Popis: | International audience; Human anterior gradient proteins AGR2 and AGR3 are overexpressed in a variety of adenocarcinomas and are often secreted in cancer patients' specimens, which suggests a role for AGR proteins in intra and extracellular compartments. Although these proteins exhibit high sequence homology, AGR2 is predominantly described as a pro-oncogene and a potential prognostic biomarker. However, little is known about the function of AGR3. Therefore, the aim of the present study was to investigate the role of AGR3 in breast cancer. The results demonstrated that breast cancer cells secrete AGR3. Furthermore, it was revealed that extracellular AGR3 (eAGR3) regulates tumor cell adhesion and migration. The current study indicated that the pharmacological and genetic perturbation of Src kinase signaling, through treatment with Dasatinib (protein kinase inhibitor) or investigating cells that express a dominant-negative form of Src, significantly abrogated eAGR3-mediated breast cancer cell migration. Therefore, the results indicated that eAGR3 may control tumor cell migration via activation of Src kinases. The results of the present study indicated that eAGR3 may serve as a microenvironmental signaling molecule in tumor-associated processes. |
| Databáze: | OpenAIRE |
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