Magnetic resonance imaging and symptoms in patients with neurosarcoidosis and central diabetes insipidus
| Autor: | Ryosuke Fujita, Akane Hirotani, Eiichi Kakehi, Kazuhiko Kotani, Hiroyuki Teraura, Shigehisa Sakurai, Masami Matsumura, Kaduyo Shimizu, Hisanori Danbara, Seiji Adachi, Yasuhiro Hashimoto, Yusuke Fukuyasu |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male Pediatrics medicine.medical_specialty Sarcoidosis Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Polyuria Central Nervous System Diseases medicine Humans Pathological Pituitary stalk medicine.diagnostic_test business.industry Neurosarcoidosis Magnetic resonance imaging medicine.disease Diabetes Insipidus Neurogenic Pituitary Gland Diabetes insipidus Prednisolone Female medicine.symptom business Polydipsia medicine.drug |
| Zdroj: | Endokrynologia Polska. 70(5) |
| ISSN: | 2299-8306 |
| Popis: | Introduction: In the clinical setting, the diagnosis of neurosarcoidosis in patients with central diabetes insipidus (CDI) is typically based both on symptoms (i.e. polydipsia or polyuria) and brain magnetic resonance imaging (MRI) findings (e.g. pituitary abnormality). However, inconsistent changes in the patient’s symptoms and brain MRI findings may occur during the clinical course of the disease. This review was performed to summarise the relationship between symptoms and brain MRI findings in previously reported cases of neurosarcoidosis with CDI. Material and methods: Case studies of patients diagnosed with neurosarcoidosis with CDI were collected via a PubMed search of studies published through 30 June 2018. Results: Thirteen eligible studies were reviewed (20 patients; 12 men, 8 women; mean age 33 years). Polydipsia or polyuria was the first symptom in 13 patients. The mean duration from disease onset to diagnosis was 3.4 months. Brain MRIs showed abnormal findings in the hypothalamus and pituitary for 17 patients. Immunosuppressive drugs were used in 17 patients. For 14 patients, MRI findings improved, while symptoms did not. Conclusion: Patients with both neurosarcoidosis and CDI symptoms often do not improve, despite the fact that brain MRI findings often improve following treatment. More studies involving detailed pathological analyses and longer follow-up periods are necessary. |
| Databáze: | OpenAIRE |
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