Neuropathologic correlates of amyloid and dopamine transporter imaging in Lewy body disease
| Autor: | Aaron P. Schultz, Stephen N. Gomperts, Nathan F. Clement, Rong Ye, Samantha Katz, Matthew P. Frosch, Julia Shirvan, John H. Growdon, Keith A. Johnson, Teresa Gomez-Isla |
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| Rok vydání: | 2019 |
| Předmět: |
Lewy Body Disease
Male 0301 basic medicine Pathology medicine.medical_specialty Amyloid Contrast Media Standardized uptake value Article 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Cocaine mental disorders Humans Medicine Senile plaques Aged Aged 80 and over Dopamine Plasma Membrane Transport Proteins Amyloid beta-Peptides Aniline Compounds Lewy body business.industry Dementia with Lewy bodies Brain Parkinson Disease Neurofibrillary tangle Middle Aged medicine.disease Thiazoles 030104 developmental biology chemistry Positron-Emission Tomography Female Autopsy Neurology (clinical) Cerebral amyloid angiopathy Pittsburgh compound B business 030217 neurology & neurosurgery |
| Zdroj: | Neurology |
| ISSN: | 1526-632X 0028-3878 |
| Popis: | ObjectiveTo develop imaging biomarkers of diseases in the Lewy body spectrum and to validate these markers against postmortem neuropathologic findings.MethodsFour cognitively normal participants with Parkinson disease (PD), 4 with PD with cognitive impairments, and 10 with dementia with Lewy bodies underwent amyloid imaging with [11C]Pittsburgh compound B (PiB) and dopamine transporter (DAT) imaging with [11C]Altropane. All 18 had annual neurologic examinations. All cognitively normal participants with PD developed cognitive impairment before death. Neuropathologic examinations assessed and scored Braak Lewy bodies, Thal distribution of amyloid, Consortium to Establish a Registry for Alzheimer's Disease neuritic amyloid plaques, Braak neurofibrillary tangles, and cerebral amyloid angiopathy, as well as total amyloid plaque burden in the superior frontal, superior parietal, occipital, and inferior temporal cortical regions. PET data were expressed as the standardized uptake value ratio with cerebellar reference. Analyses accounted for the interval between imaging and autopsy.ResultsAll 18 patients met neuropathologic criteria for Lewy body disease; the DAT concentration was low in each case. All patients with elevated [11C]PiB retention measured in a neocortical aggregate had β-amyloid deposits at autopsy. [11C]PiB retention significantly correlated with neuritic plaque burden and with total plaque burden. [11C]PiB retention also significantly correlated with the severity of both Braak stages of neurofibrillary tangle and Lewy body scores. Neuritic plaque burden was significantly associated with neurofibrillary tangle pathology.ConclusionAntemortem [11C]Altropane PET is a sensitive measure of substantia nigra degeneration. [11C]PiB scans accurately reflect cortical amyloid deposits seen at autopsy. These findings support the use of molecular imaging in the evaluation of patients with Lewy body diseases. |
| Databáze: | OpenAIRE |
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