Prevalence of anal intraepithelial neoplasia in women with genital neoplasia
| Autor: | Cléia Bertinetti Bandeira, Margarete Ribeiro Duarte Rosa, Renato Borges Fagundes, Eduardo Cambruzzi, Daniela Cerqueira Koppe, Luise Meurer |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Biopsy Genital neoplasia Uterine Cervical Neoplasms Proctoscopy Normal results Statistics Nonparametric Surveys and Questionnaires Epidemiology medicine Prevalence Humans Prevalence ratio Gynecology Intraepithelial neoplasia Chi-Square Distribution medicine.diagnostic_test business.industry Gastroenterology Anal intraepithelial neoplasia Anoscopy General Medicine Anus Anus Neoplasms Uterine Cervical Dysplasia medicine.anatomical_structure Cross-Sectional Studies Colposcopy Female business Brazil Carcinoma in Situ |
| Zdroj: | Diseases of the colon and rectum. 54(4) |
| ISSN: | 1530-0358 |
| Popis: | Anal intraepithelial neoplasia is believed to be a precursor of anal cancer, and it appears to be related to high-risk human papillomavirus. Women with genital neoplasia have been shown to be at increased risk for anal cancer.The aim of this study is to determine the prevalence of anal intraepithelial neoplasia in women with genital neoplasia.This is a cross-sectional study.This study took place at Hospital Nossa Senhora da Conceição, Porto Alegre, Brazil, from May 2008 to April 2010.Included in the study were 106 immunocompetent women with a histopathological diagnosis of genital neoplasia and 74 women without gynecologic neoplasia.All women underwent high-resolution anoscopy with biopsies of acetowhite areas or abnormal vascular features such as punctation and mosaics for histopathological diagnosis of anal intraepithelial neoplasia.: The overall prevalence of anal intraepithelial neoplasia was 6.6%. In women with genital neoplasia, the prevalence was 10.4% (95% CI, 5.6%-17.3%), whereas the prevalence was 1.4% (95% CI, 0.07%-6.5%) in women without genital neoplasia (P = .016). The prevalence ratio was 7.68 (95% CI, 1.01-58.21).Women with normal results on high-resolution anoscopy were not submitted to random biopsies for ethical reasons. Small lesions could be missed, and thus our findings might be underestimated.The prevalence of anal intraepithelial neoplasia is higher in women with genital neoplasia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|