Metastatic adrenocortical carcinoma treated with sunitinib: a case report
| Autor: | Hee Eun Lee, Chung Jong Kim, Haeryoung Kim, Jee Hyun Kim, Keun-Wook Lee, Jong-Seok Lee, Jeong Ok Lee, Soo Mee Bang, Yu Jung Kim, Jae Sung Kim |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Indoles medicine.medical_treatment Angiogenesis Inhibitors Antineoplastic Agents urologic and male genital diseases Malignancy Young Adult Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Sunitinib Adrenocortical carcinoma Humans Radiology Nuclear Medicine and imaging Mitotane Pyrroles Treatment Failure Chemotherapy business.industry Carcinoma Cancer General Medicine medicine.disease Chemotherapy regimen female genital diseases and pregnancy complications Adrenal Cortex Neoplasms Radiation therapy Treatment Outcome Drug Resistance Neoplasm Radiotherapy Adjuvant business medicine.drug |
| Zdroj: | Japanese journal of clinical oncology. 39(3) |
| ISSN: | 1465-3621 |
| Popis: | Adrenocortical carcinoma (ACC) is a rare malignancy with poor prognosis. Palliative chemotherapy can be considered in patients with metastatic disease. Although mitotane- or cisplatin-based chemotherapy regimens are widely used, the effects of these agents have been limited. We have experienced a case that showed a partial response with sunitinib after failure of mitotane-based cytotoxic chemotherapy. The clinical benefit from sunitinib persisted 7.5 months in this case. To our knowledge, this is the first reported case showing the effects of sunitinib on metastatic ACC. |
| Databáze: | OpenAIRE |
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