Historical perspective on the department of energy mortality studies: focus on the collection and storage of individual worker data
| Autor: | David J. Girardi, Phil W Wallace, Joyce Phillips, Elizabeth D. Ellis, Donna L. Cragle, Ashley P. Golden |
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| Rok vydání: | 2019 |
| Předmět: |
Protocol (science)
Focus (computing) Radiological and Ultrasound Technology Process (engineering) Computer science MEDLINE Construct (python library) Data science 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Resource (project management) Radiation Ionizing 030220 oncology & carcinogenesis Cohort Data file Humans Radiology Nuclear Medicine and imaging |
| Zdroj: | International Journal of Radiation Biology. 98:560-567 |
| ISSN: | 1362-3095 0955-3002 |
| Popis: | Purpose To present how the Department of Energy's (DOE) Comprehensive Epidemiologic Data Resource (CEDR) is integrated into the Million Person Study of Low Dose Health Effects (MPS). The history of DOE's worker health surveillance and its epidemiology program are described. Methods and materials A standard protocol is used to extract data from CEDR for use in the MPS. The data files are pulled from CEDR to form the basis for the cohort analyzed in the MPS. The previous study data are reviewed to formulate the protocol for the MPS study cohort. The activities needed to update the data to construct the new analytic files are carried out in parallel. The primary efforts relate to updating the vital status, retrieving cause of death information and calculating annual radiation doses for the specific organs of interest. Working data files containing the updated data are produced for construction of analytic data files used in the biostatistical analysis. At study completion the working and analytic data files are placed into CEDR for use by other researchers. Results The use of CEDR to study the scientific and maintenance workers at the Los Alamos National Laboratory which is currently underway is used to demonstrate the process. Conclusions There is a pressing need to answer the question of the health risk of exposure to chronic low level exposure to ionizing radiation. Using CEDR as the starting point to identify new cohorts to include in the MPS is a cost effective and a time efficient way to expedite answering this question. |
| Databáze: | OpenAIRE |
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