Inhibition of spinal reflexes by acetylsalicylate and metamizol (dipyrone) in rats

Autor: Osman Genç, S Kortunay, Günfer Turgut, S. Turgut
Rok vydání: 2003
Předmět:
Decerebrate State
medicine.medical_treatment
Dipyrone
Stimulation
sciatic nerve
nerve stimulation
Spinal reflexes
chemistry.chemical_compound
rat
statistical significance
biology
Reflex
Monosynaptic
Anti-Inflammatory Agents
Non-Steroidal
article
Laminectomy
artificial ventilation
electrostimulation
General Medicine
anesthetic agent
priority journal
Spinal Cord
Anesthesia
acetylsalicylic acid calcium
Arachidonic acid
Sciatic nerve
spinal reflex
prostaglandin synthase inhibitor
medicine.drug
ketamine
Animals
Anti-Inflammatory Agents
Non-Steroidal/administration & dosage/*pharmacology
Aspirin/administration & dosage/*pharmacology
Dipyrone/administration & dosage/*pharmacology
Lumbosacral Region
Rats
Rats
Wistar
Reflex
Monosynaptic/*drug effects
Spinal Cord/*drug effects/physiology
Acetylsalicylate
animal experiment
Spinalized rat
anesthesia
inhibition kinetics
medicine
Ketamine
controlled study
Pharmacology
nonhuman
Aspirin
business.industry
laminectomy
Metamizol (dipyrone)
back
chemistry
biology.protein
Reflex
Cyclooxygenase
business
monosynaptic reflex
Zdroj: Pharmacology. 69(3)
ISSN: 0031-7012
Popis: The effects of acetylsalicylate and metamizol on spinal monosynaptic reflexes were tested in spinal rats. Adult rats were anesthetized with ketamine, artificially ventilated, and spinalized at the C1 level. A laminectomy was performed in the lumbosacral region. Following electrical stimulation of the sciatic nerve by single pulses, the reflex potentials were recorded from the ipsilateral L5 ventral root. Acetylsalicylate was administered orally via nasogastric tube and metamizol intramuscularly. Acetylsalicylate (50 and 100 mg/kg) and metamizol (15 mg/kg) significantly decreased the amplitude of the reflex response (p < 0.05). But the 10-mg/kg metamizol dose did not significantly decrease the amplitude of the reflex response. The cyclooxygenase products of arachidonic acid may play an important role in regulating the reflex potential. Copyright © 2003 S. Karger AG, Basel.
Databáze: OpenAIRE
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