Evaluation of depressive mood and cognitive functions in patients with acromegaly under somatostatin analogue therapy
| Autor: | D. Gogas Yavuz, Kayihan Uluc, Hande Alibaş, Tulin Tanridag, Nese Tuncer, Melin Uygur, P. Kahraman Koytak |
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| Rok vydání: | 2017 |
| Předmět: |
Depressive mood
Adenoma Adult Male medicine.medical_specialty Adolescent Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Affect (psychology) Gastroenterology 03 medical and health sciences Young Adult 0302 clinical medicine Endocrinology Pituitary adenoma Internal medicine Acromegaly medicine Verbal fluency test Humans Cognitive Dysfunction Pituitary Neoplasms Insulin-Like Growth Factor I Aged Depressive Disorder business.industry Human Growth Hormone Cognition Middle Aged medicine.disease Prognosis Peripheral neuropathy Concomitant Case-Control Studies Female business 030217 neurology & neurosurgery Follow-Up Studies |
| Zdroj: | Journal of endocrinological investigation. 40(12) |
| ISSN: | 1720-8386 |
| Popis: | Acromegaly is caused by a pituitary adenoma that releases excess growth hormone (GH) and a concomitant increase in insulin-like growth factor 1 (IGF-1). Acromegaly results not only in phenotypic changes, but also in neurologic complications as peripheral neuropathy and cognitive dysfunction. This study aimed to compare depressive mood and cognitive function in patients with acromegaly and in healthy controls as well as to determine the factors underlying cognitive dysfunction in the acromegalic patients. This study included 42 patients with acromegaly that were receiving somatostatin analogue therapy and 44 healthy controls. Memory, attention, visuospatial function, inhibitory function, abstract thinking, verbal fluency, and depressive mood were measured in the patients and controls. Patients with acromegaly had lower learning (p = 0.01), planning (p = 0.03), complex attention and inhibitory function (p = 0.04) scores than the controls. There was no significant difference in depressive mood between the patients and controls (p > 0.05). Gamma knife radiosurgery did not negatively affect cognitive function (p > 0.05). The present findings show that acromegaly negatively affects learning, attention, and planning. |
| Databáze: | OpenAIRE |
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