Serum nesfatin in overweight and obese children
| Autor: | Olga P. Kovtun, Arina Maksimova, Larisa Polushina, Elena V. Anufrieva, V V Bazarnyi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
child obesity Nutrition and Dietetics business.industry Physiology Endocrinology Diabetes and Metabolism Public Health Environmental and Occupational Health cholesterol nesfatin-1 QD415-436 Overweight Biochemistry Endocrinology Internal medicine Internal Medicine Medicine overweight QP1-981 medicine.symptom business |
| Zdroj: | Ожирение и метаболизм, Vol 17, Iss 2, Pp 200-207 (2020) |
| ISSN: | 2306-5524 2071-8713 |
| Popis: | BACKGROUND: Obesity is one of the most common children diseases. In present time it is being actively studied the natural hormones role in the pathogenesis of obesity. AIMS: To determine the relationship between serum nesfatin level with impaired lipid metabolism in school age children with overweight and obesity. MATERIALS AND METHODS: The study included children with overweight and obesity (case) and healthy children with normal body mass (control) aged 9 to 15 years. All children were determined by concentration in cholesterol blood and its factions, apoA-1, apoB. Enzyme-linked immunosorbent assay (Bio Human Nesfatin Enzyme Immunoassay Kit). RESULTS: Groups of patients with overweight and obesity (n = 53) and healthy children (n = 31) were comparable by age and sex. In obese children, a significant decrease in the level of nesfatin-1 was revealed compared with the group with normal body weight. In cases of children obesity there is a marked decrease in the concentration of nesfatin-1 in serum, especially expressed in the dyslipidemia presence. The nesfatin-1 level are negatively correlated to BMI and body fat content. CONCLUSIONS: The obtained data suggest that along with the known key role of nesfatin in the regulation of eating behavior and appetite, it also affects anthropometric indicators, primarily associated with the accumulation of excess fat mass. Based on the data obtained, nesfatin-1 should be considered as a possible marker for the development of obesity in children. |
| Databáze: | OpenAIRE |
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