A role for hypertrophic astrocytes and astrocyte precursors in a case of rapidly progressive multiple sclerosis
| Autor: | Sangmin Lee, Michael C. Levin, Yvette Morcos |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Male
Pathology medicine.medical_specialty Multiple Sclerosis Population Nerve Fibers Myelinated White matter Lesion 03 medical and health sciences Myelin Fatal Outcome 0302 clinical medicine Glial Fibrillary Acidic Protein medicine Humans Vimentin 030212 general & internal medicine Remyelination education education.field_of_study Glial fibrillary acidic protein biology Stem Cells Multiple sclerosis Brain Middle Aged medicine.disease Nerve Regeneration medicine.anatomical_structure Neurology Astrocytes Disease Progression biology.protein Neurology (clinical) medicine.symptom 030217 neurology & neurosurgery Astrocyte |
| Zdroj: | Multiple Sclerosis Journal. 9:332-341 |
| ISSN: | 1477-0970 1352-4585 |
| DOI: | 10.1191/1352458503ms931oa |
| Popis: | The purpose of this study was to examine the roles played by astrocytes in a case of rapidly progressive multiple sclerosis (MS). Within early-active and active lesions, hypertrophic astrocytes played an important role in lesion patho logy through the phagocytosis of myelin and axonal debris and through the internalization of other glial cells, including astrocytes. In addition to this critical role, hypertrophic astrocytes, in areas that lack significant inflammation (within the adjacent normal appearing white matter and within late remyelinating lesions) were found to be active in myelin and axonal debris phagocytosis with no evidence of cellular internalization. Hypertrophic astrocytes therefore not only play an important role in the patho genesis of MS lesions but also exert a continued deleterio us effect upon tissue in the absence of significant inflammation. In addition, we found evidence for a significant population of vimentin-positive, glial fibrillary acidic protein (GFA P)-negative, bipolar, astrocyte precursors within the late remyelinating lesions. Their significance is not known but a possible role may include their participatio n in the successful remyelination of the lesion. |
| Databáze: | OpenAIRE |
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