Predominant Expression of Murine Bmx Tyrosine Kinase in the Granulo-Monocytic Lineage
Autor: | Chung Leung Li, Dominique Weil, Maryanne Power, Shirley I. Smith |
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Přispěvatelé: | Compartimentation et trafic intracellulaire des mRNP = Compartmentation and intracellular traffic of mRNPs (LBD-E14), Laboratoire de Biologie du Développement [Paris] (LBD), Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Institut de Biologie Paris Seine (IBPS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
Rok vydání: | 1997 |
Předmět: |
Adult
Neutrophils Cellular differentiation Molecular Sequence Data Population Immunology Cell Separation Biology Biochemistry Monocytes Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Humans Bruton's tyrosine kinase [SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology Amino Acid Sequence Cloning Molecular Progenitor cell education 030304 developmental biology education.field_of_study 0303 health sciences Macrophages Hematopoietic stem cell Cell Differentiation Cell Biology Hematology Protein-Tyrosine Kinases Flow Cytometry Hematopoietic Stem Cells Molecular biology medicine.anatomical_structure 030220 oncology & carcinogenesis Cancer research biology.protein Stem cell Tyrosine kinase Granulocytes 030215 immunology Proto-oncogene tyrosine-protein kinase Src |
Zdroj: | Europe PubMed Central Blood Blood, American Society of Hematology, 1997, 90 (11), pp.4332-40 |
ISSN: | 1528-0020 0006-4971 |
Popis: | In the course of systematic cloning of protein tyrosine kinases (PTKs) expressed in hematopoietic stem and progenitor cells, we have identified the murine homologue of human Bmx. It encodes a protein containing the five domains characteristic of the Tec family of cytoplasmic src-related PTKs: pleckstrin homology (PH), Tec homology (TH), src homology 3 and 2 (SH3 and SH2), and tyrosine kinase (TK). In adults, Bmx expression was found primarily in bone marrow and at a lower level in lung and heart. During fetal development it was also found in the spleen at late stage of gestation and in neonates. Analysis of bone marrow subpopulations showed that Bmx was expressed in the progenitor cell population and maturing hematopoietic cells of the granulo/monocytic lineage where expression increased with maturation and differentiation. At the periphery, a high level of Bmx expression was also found in neutrophils and monocytes/macrophages. Bmx expression was not detected in the primitive hematopoietic stem cell population, and cells of the B-, T-, and erythroid-lineages. It was also not detected in most of the cell lines examined. Our results indicate that Bmx is another member of the Btk/Itk/Tec PTK family, which is predominantly expressed in the granulo-monocytic lineage within the hematopoietic system. |
Databáze: | OpenAIRE |
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