Combination Hormonotherapy with Tamoxifen and Fluoxymesterone in Patients with Advanced Breast Cancer Relapsing on Hormonotherapy
| Autor: | Urs A. Leuenberger, Aron Goldhirsch, Sonntag Rw, Franco Cavalli, Joss R, Ryssel Hj, Kurt W. Brunner |
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| Rok vydání: | 1982 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Advanced breast Fluoxymesterone Breast Neoplasms Partial response Internal medicine medicine Humans In patient Aged Clinical Trials as Topic business.industry Cancer General Medicine Middle Aged medicine.disease Tamoxifen Drug Therapy Combination Female business medicine.drug |
| Zdroj: | Oncology. 39:284-286 |
| ISSN: | 1423-0232 0030-2414 |
| DOI: | 10.1159/000225652 |
| Popis: | 33 patients were treated with a combination of tamoxifen and fluoxymesterone (10 mg t.i.d. each) after progression on prior hormonotherapy (HT). 6 of 22 patients (27%) exhibiting a partial response (PR) or stable disease (NC) on previous HT responded to the combination (median time to relapse 7 months, range 3.5 to 17+ months). 11 (50%) maintained NC (median duration 5 months, range 2% to 9.5 months). No response has been seen in 11 patients who experienced progressive disease during prior hormonal manipulation or who were not evaluable for response to prior HT. The overall response rate was 18% for the patient population as a whole (responders and nonresponders to previous HT), which most probably would be similar to the response rate if these patients received only fluoxymesterone. |
| Databáze: | OpenAIRE |
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