Postpartum cervical repair in mice: a morphological characterization and potential role for angiogenic factors
Autor: | Takako Ohashi, Chishimba Nathan Mowa, Robert Lee Stanley |
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Rok vydání: | 2014 |
Předmět: |
Vascular Endothelial Growth Factor A
medicine.medical_specialty Histology Future studies VEGF receptors Cervicitis Cervix Uteri Bioinformatics Pathology and Forensic Medicine chemistry.chemical_compound Mice Pregnancy Medicine Animals Humans Cervix reproductive and urinary physiology Gynecology Wound Healing biology business.industry Cervical lacerations Postpartum Period Ectropion Cell Biology medicine.disease Molecular medicine Vascular Endothelial Growth Factor Receptor-2 Vascular endothelial growth factor medicine.anatomical_structure chemistry biology.protein Angiogenesis Inducing Agents Female business |
Zdroj: | Cell and tissue research. 362(1) |
ISSN: | 1432-0878 |
Popis: | The cervix undergoes marked mechanical trauma during delivery of the baby at birth. As such, a timely and complete tissue repair postpartum is necessary to prevent obstetrical complications, such as cervicitis, ectropion, hemorrhage, repeated miscarriages or abortions and possibly preterm labor and malignancies. However, our knowledge of normal cervical repair is currently incomplete and factors that influence repair are unclear. Here, we characterize the morphological and angiogenic profile of postpartum repair in mice cervix during the first 48 h of postpartum. The key findings presented here are: (1) cervical epithelial folds and size are diminished during the first 48 h of postpartum repair, (2) hypoxic inducible factor 1a, vascular endothelial growth factor (VEGF), and VEGF receptor 1 expression are pronounced early in postpartum cervical repair, and (3) VEGF receptor 2 gene and protein expressions are variable. We conclude that postpartum cervical repair involves gross and microscopic changes and is linked to expression of angiogenic factors. Future studies will assess the suitability of these factors, identified in the present study, as potential markers for determining the phase of postpartum cervical repair in obstetrical complications, such as cervical lacerations. |
Databáze: | OpenAIRE |
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