Scope of Outcomes in Trials and Observational Studies of Interventions Targeting Medication Adherence in Rheumatic Conditions: A Systematic Review
| Autor: | Daniel Sumpton, Robin Christensen, Shahrzad Salmasi, Vicki Evans, Kathleen Tymms, Suzanne M M Verstappen, Karine E. Manera, Charlotte L Bekker, Bart J F van den Bemt, Mary A. De Vera, Peter Tugwell, Ayano Kelly, Susan J. Bartlett, Lyn March, Robby Nieuwlaat, Luke Crimston-Smith, Marieke Scholte-Voshaar, Allison Tong, Maarten de Wit, Jasvinder A. Singh, Michael Gill, Karine Toupin-April |
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| Přispěvatelé: | Psychology, Health & Technology |
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Immunology Psychological intervention Healthcare improvement science Radboud Institute for Health Sciences [Radboudumc 18] law.invention Medication Adherence 03 medical and health sciences 0302 clinical medicine Clinical trials Rheumatic diseases Rheumatology Quality of life Randomized controlled trial law Internal medicine Rheumatic Diseases medicine Immunology and Allergy Outcome assessment (health care) Humans 030212 general & internal medicine Satisfaction with Medication Adverse effect Medication adherence 030203 arthritis & rheumatology business.industry Patient compliance n/a OA procedure Clinical trial Research Design Systematic review Quality of Life Observational study business |
| Zdroj: | Kelly, A, Crimston-Smith, L, Tong, A, Bartlett, S J, Bekker, C, Christensen, R, De Vera, M A, de Wit, M, Evans, V, Gill, M, March, L, Manera, K, Nieuwlaat, R, Salmasi, S, Scholte-Voshaar, M, Singh, J A, Sumpton, D, Toupin-April, K, Tugwell, P, van den Bemt, B, Verstappen, S & Tymms, K 2020, ' Scope of outcomes in trials and observational studies of interventions targeting medication adherence in rheumatic conditions : A systematic review ', Journal of Rheumatology, vol. 47, no. 10, pp. 1565-1574 . https://doi.org/10.3899/jrheum.190726 The Journal of Rheumatology, 47, 10, pp. 1565-1574 Journal of rheumatology, 47(10), 1565-1574. Journal of Rheumatology The Journal of Rheumatology, 47, 1565-1574 |
| ISSN: | 0315-162X |
| Popis: | Objective.Nonadherence to medications is common in rheumatic conditions and associated with increased morbidity. Heterogeneous outcome reporting by researchers compromises the synthesis of evidence of interventions targeting adherence. We aimed to assess the scope of outcomes in interventional studies of medication adherence.Methods.We searched electronic databases to February 2019 for published randomized controlled trials and observational studies of interventions with the primary outcome of medication adherence including adults with any rheumatic condition, written in English. We extracted and analyzed all outcome domains and adherence measures with prespecified extraction and analysis protocols.Results.Overall, 53 studies reported 71 outcome domains classified into adherence (1 domain), health outcomes (38 domains), and adherence-related factors (e.g., medication knowledge; 32 domains). We subdivided adherence into 3 phases: initiation (n = 13 studies, 25%), implementation (n = 32, 60%), persistence (n = 27, 51%), and phase unclear (n = 20, 38%). Thirty-seven different instruments reported adherence in 115 unique ways (this includes different adherence definitions and calculations, metric, and method of aggregation). Forty-one studies (77%) reported health outcomes. The most frequently reported were medication adverse events (n = 24, 45%), disease activity (n = 11, 21%), bone turnover markers/physical function/quality of life (each n = 10, 19%). Thirty-three studies (62%) reported adherence-related factors. The most frequently reported were medication beliefs (n = 8, 15%), illness perception/medication satisfaction/satisfaction with medication information (each n = 5, 9%), condition knowledge/medication knowledge/trust in doctor (each n = 3, 6%).Conclusion.The outcome domains and adherence measures in interventional studies targeting adherence are heterogeneous. Consensus on relevant outcomes will improve the comparison of different strategies to support medication adherence in rheumatology. |
| Databáze: | OpenAIRE |
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