Serology reveals heterogeneity of Plasmodium falciparum transmission in northeastern South Africa: implications for malaria elimination
| Autor: | Eunice Agubuzo, Immo Kleinschmidt, Jaishree Raman, Aaron Mabuza, Philip Kruger, Maureen Coetzee, Elliot Machaba, Ishen Serocharan, Khumbulani Hlongwana, Joseph R. Biggs, Jackie Cook, Alpheus Zitha, Natashia Morris, Chris Drakeley |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Male
Indoor residual spraying South Africa 0302 clinical medicine Hotspot Risk Factors Seroepidemiologic Studies Prevalence Cluster Analysis 030212 general & internal medicine Malaria Falciparum Child education.field_of_study Incidence Age Factors Middle Aged 3. Good health PfAMA-1 Infectious Diseases Serology Child Preschool Female Adult medicine.medical_specialty Adolescent Elimination 030231 tropical medicine Population Plasmodium falciparum Biology 03 medical and health sciences Young Adult Environmental health parasitic diseases medicine Seroprevalence Humans Transmission Seroconversion PfMSP-119 education Research Apical membrane medicine.disease biology.organism_classification Malaria Cross-Sectional Studies Tropical medicine Immunology Parasitology Heterogeneity |
| Zdroj: | Malaria Journal |
| ISSN: | 1475-2875 |
| Popis: | Background It is widely acknowledged that modifications to existing control interventions are required if South Africa is to achieve malaria elimination. Targeting indoor residual spraying (IRS) to areas where cases have been detected is one strategy currently under investigation in northeastern South Africa. This seroprevalence baseline study, nested within a targeted IRS trial, was undertaken to provide insights into malaria transmission dynamics in South Africa and evaluate whether sero-epidemiological practices have the potential to be routinely incorporated into elimination programmes. Methods Filter-paper blood spots, demographic and household survey data were collected from 2710 randomly selected households in 56 study wards located in the municipalities of Ba-Phalaborwa and Bushbuckridge. Blood spots were assayed for Plasmodium falciparum apical membrane antigen-1 and merozoite surface protein-119 blood-stage antigens using an enzyme linked immunosorbent assay. Seroprevalence data were analysed using a reverse catalytic model to determine malaria seroconversion rates (SCR). Geospatial cluster analysis was used to investigate transmission heterogeneity while random effects logistic regression identified risk factors associated with malaria exposure. Results The overall SCR across the entire study site was 0.012 (95% CI 0.008–0.017) per year. Contrasting SCRs, corresponding to distinct geographical regions across the study site, ranging from |
| Databáze: | OpenAIRE |
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