Adenosine triphosphoric acid as a factor of nervous regulation of Na+/K+/2Cl- cotransport in rat skeletal muscle fibers
| Autor: | A. Kh. Urazaev, A. V. Shakirzyanova, Andrey L. Zefirov, K.V. Uzinskaya, N. V. Naumenko |
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| Rok vydání: | 2009 |
| Předmět: |
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medicine.medical_specialty Membrane permeability Muscle Fibers Skeletal General Biochemistry Genetics and Molecular Biology Membrane Potentials chemistry.chemical_compound Adenosine Triphosphate Sarcolemma Chlorides Postsynaptic potential Internal medicine medicine Repolarization Animals Protein Kinase C Membrane potential Chemistry Receptors Purinergic P2 Sodium Depolarization Biological Transport General Medicine Adenosine Acetylcholine Rats Endocrinology Biophysics Potassium Triphosphoric acid medicine.drug |
| Zdroj: | Bulletin of experimental biology and medicine. 147(5) |
| ISSN: | 1573-8221 |
| Popis: | Exogenous adenosine triphosphoric acid produces a biphasic effect on the resting membrane potential of muscle fibers in rat diaphragm. Depolarization of the sarcolemma observed 10 min after application of adenosine triphosphoric acid results from activation of Na(+)/K(+)/2Cl(-) cotransport. The increase in chloride cotransport is related to activation of postsynaptic P2Y receptors and protein kinase C. Repolarization of the membrane develops 40 min after treatment with adenosine triphosphoric acid and after 50 min the resting membrane potential almost returns the control level. This increase in the resting membrane potential of the sarcolemma is probably associated with activation of the Na(+)/K(+) pump and increase in membrane permeability for chlorine ions in response to long-term activity of Cl(-) cotransport. Thus, adenosine triphosphoric acid co-secreted with acetylcholine in the neuromuscular synapse probably plays a role in the regulation resting membrane potential and cell volume of muscle fibers. |
| Databáze: | OpenAIRE |
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