Control of antimicrobial peptide synthesis by the agr quorum sensing system in Staphylococcus epidermidis: activity of the lantibiotic epidermin is regulated at the level of precursor peptide processing
| Autor: | Friedrich Götz, Stefanie Kies, Cornelia Meyer, Michael Otto, Andreas Peschel, Matthias Hille, Cuong Vuong |
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| Rok vydání: | 2003 |
| Předmět: |
Signal peptide
Physiology medicine.medical_treatment Molecular Sequence Data Virulence medicine.disease_cause Biochemistry Microbiology Cellular and Molecular Neuroscience Endocrinology Bacterial Proteins Bacteriocins Staphylococcus epidermidis medicine Amino Acid Sequence Protein Precursors Promoter Regions Genetic Peptide sequence Sequence Deletion Protease biology Chemistry Gene Expression Regulation Bacterial biochemical phenomena metabolism and nutrition Lantibiotics bacterial infections and mycoses biology.organism_classification Quorum sensing Genes Bacterial Staphylococcus aureus bacteria Electrophoresis Polyacrylamide Gel Peptides Protein Processing Post-Translational |
| Zdroj: | Peptides. 24:329-338 |
| ISSN: | 0196-9781 |
| DOI: | 10.1016/s0196-9781(03)00046-9 |
| Popis: | The accessory gene regulator (agr) quorum sensing system in staphylococci is responsible for the regulation of surface proteins and exoproteins, including many virulence factors in the pathogenic species Staphylococcus aureus and S. epidermidis. Strain S. epidermidis Tü3298 produces the lantibiotic epidermin. An isogenic agr deletion mutant of this strain showed a strong reduction of epidermin production. Detailed analysis of the impact of agr on epidermin biosynthesis revealed that agr does not interfere with the transcription of epidermin biosynthetic genes, but controls the extracellular processing of the N-terminal leader peptide by the EpiP protease. |
| Databáze: | OpenAIRE |
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