Effect of neoadjuvant chemotherapy for lymph node micrometastasis and tumor cell microinvolvement in the patients with esophageal carcinoma
| Autor: | Sonshin Takao, Saburo Nakashima, Kuniaki Aridome, Sumiya Ishigami, Hiroshi Okumura, Chikara Kusano, Futoshi Miyazono, Fumio Kijima, Masamichi Baba, Takashi Aikou, Masataka Matsumoto, Shoji Natsugoe |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Esophageal Neoplasms medicine.medical_treatment Leucovorin Gastroenterology Metastasis Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Lymph node Aged Chemotherapy business.industry Micrometastasis Esophageal cancer Middle Aged medicine.disease Combined Modality Therapy Immunohistochemistry Neoadjuvant Therapy Esophagectomy Survival Rate medicine.anatomical_structure Treatment Outcome Epidermoid carcinoma Lymphatic Metastasis Carcinoma Squamous Cell Keratins Female Lymph Fluorouracil Cisplatin business Follow-Up Studies |
| Zdroj: | Cancer letters. 159(2) |
| ISSN: | 0304-3835 |
| Popis: | Micrometastasis (MM) and tumor cell microinvolvement (TCM) in the lymph node were immunohistochemically evaluated using the cytokeratin (CK) antibody between a surgery group (n=20; 929 lymph nodes) and a chemotherapy group (n=20; 1052 lymph nodes). The incidence of MM±TCM in the surgery and chemotherapy groups was 50.0 (10/20) and 55.0% (11/20), respectively. Limiting the analysis to TCM alone revealed that the incidence in the chemotherapy group (10.0%; 2/20) was significantly lower than that in the surgery group (40.0%; 8/20; P=0.032). Preoperative chemotherapy in this regime was not effective, except for some patients with TCM alone. |
| Databáze: | OpenAIRE |
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