A phase I-II study of high-dose melphalan, mitoxantrone and carboplatin with peripheral blood stem cell support in patients with advanced ovarian or breast carcinoma
| Autor: | WH West, M Lewis, P Baldwin, C H Weaver, F Wittlin, B Zhen, Lee S. Schwartzberg, J Hainsworth, Buckner Cd, FA Greco |
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| Rok vydání: | 1997 |
| Předmět: |
Melphalan
Adult medicine.medical_specialty endocrine system diseases medicine.medical_treatment Urology Breast Neoplasms Disease-Free Survival Carboplatin chemistry.chemical_compound Ovarian carcinoma Antineoplastic Combined Chemotherapy Protocols medicine Carcinoma Humans Life Tables Renal Insufficiency Bone Marrow Diseases Cerebral Hemorrhage Ovarian Neoplasms Salvage Therapy Transplantation Chemotherapy Mitoxantrone business.industry Hematopoietic Stem Cell Transplantation Hematology Middle Aged medicine.disease Combined Modality Therapy female genital diseases and pregnancy complications Surgery Regimen Treatment Outcome chemistry Female business Ovarian cancer Lung Diseases Interstitial medicine.drug |
| Zdroj: | Bone marrow transplantation. 20(10) |
| ISSN: | 0268-3369 |
| Popis: | The purpose of this study was to develop a high-dose chemotherapy (HDC) and peripheral blood stem cell (PBSC) regimen for treatment of patients with ovarian carcinoma that could be administered in an outpatient setting. Fourteen patients with advanced ovarian (n = 9) or breast (n = 5) carcinoma, who had failed conventional chemotherapy, were entered into a dose-escalation trial to determine the maximum tolerated dose (MTD) of carboplatin that could be administered with fixed doses of melphalan (160 mg/m2) and mitoxantrone (50 mg/m2). Twenty-five additional patients were included in a phase II trial at the MTD. Two of two patients had grade 4 severe regimen-related toxicities (RRT), one fatal, at a dose level of 1600 mg/m2. Two of 29 patients (6.9%) treated at the MTD (carboplatin, 1400 mg/m2) died of RRT. All three patients who died of toxicity had a calculated AUC for carboplatin >30 mg/ml/min. Thirty-one patients with ovarian cancer who had failed chemotherapy were treated, 24 at the MTD. Fourteen of 20 patients (70%) with ovarian carcinoma with evaluable disease achieved a CR and seven (35%) are alive disease-free a median of 20 months (range, 7-26). Five of seven patients with ovarian cancer who had failed chemotherapy but were rendered clinically disease-free following surgery survive without progression a median of 13 months (range, 9-19). Eight of 16 (50%) platinum-resistant and 4/12 (33%) platinum-sensitive patients with ovarian cancer survive disease-free. |
| Databáze: | OpenAIRE |
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