Hemodynamics mediated epigenetic regulators in the pathogenesis of vascular diseases
| Autor: | S. Sumi, C C Kartha, S Ahalya, C L Karthika, N. Radhakrishnan |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Endothelium Hypertension Pulmonary Clinical Biochemistry Hemodynamics Bioinformatics Epigenesis Genetic Pathogenesis 03 medical and health sciences Mice 0302 clinical medicine medicine Animals Humans Epigenetics Vascular Diseases Endothelial dysfunction Molecular Biology Hemodynamic forces biology business.industry Endothelial Cells Cell Biology General Medicine DNA Methylation medicine.disease Atherosclerosis Endothelial stem cell 030104 developmental biology Histone medicine.anatomical_structure 030220 oncology & carcinogenesis biology.protein Endothelium Vascular business Protein Processing Post-Translational Biomarkers |
| Zdroj: | Molecular and cellular biochemistry. 476(1) |
| ISSN: | 1573-4919 |
| Popis: | Endothelium of blood vessels is continuously exposed to various hemodynamic forces. Flow-mediated epigenetic plasticity regulates vascular endothelial function. Recent studies have highlighted the significant role of mechanosensing-related epigenetics in localized endothelial dysfunction and the regional susceptibility for lesions in vascular diseases. In this article, we review the epigenetic mechanisms such as DNA de/methylation, histone modifications, as well as non-coding RNAs in promoting endothelial dysfunction in major arterial and venous diseases, consequent to hemodynamic alterations. We also discuss the current challenges and future prospects for the use of mechanoepigenetic mediators as biomarkers of early stages of vascular diseases and dysregulated mechanosensing-related epigenetic regulators as therapeutic targets in various vascular diseases. |
| Databáze: | OpenAIRE |
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