High-risk coronary plaque in SLE: low-attenuation non-calcified coronary plaque and positive remodelling index
| Autor: | Jessica Li, Matthew J. Budoff, George Stojan, Michelle Petri, Armin Arbab-Zadeh |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Male
Heart disease Computed Tomography Angiography medicine.medical_treatment Coronary Artery Disease 030204 cardiovascular system & hematology Cardiovascular Coronary Angiography 030218 nuclear medicine & medical imaging Coronary artery disease 0302 clinical medicine Prednisone Coronary plaque Medicine 2.1 Biological and endogenous factors Aetiology skin and connective tissue diseases Plaque Atherosclerotic Co-Morbidities screening and diagnosis Systemic lupus erythematosus General Medicine Middle Aged Plaque Atherosclerotic Detection Heart Disease 6.1 Pharmaceuticals Cardiology Biomedical Imaging Female Patient Safety Cardiac monitoring medicine.symptom medicine.drug 4.2 Evaluation of markers and technologies lcsh:Immunologic diseases. Allergy Adult medicine.medical_specialty Immunology Lupus Asymptomatic Autoimmune Disease 03 medical and health sciences Clinical Research Internal medicine lupus erythematosus systemic Humans Heart Disease - Coronary Heart Disease business.industry Evaluation of treatments and therapeutic interventions systemic medicine.disease Occult cardiovascular diseases atherosclerosis business lcsh:RC581-607 lupus erythematosus |
| Zdroj: | Lupus Science & Medicine Lupus Science and Medicine, Vol 7, Iss 1 (2020) Lupus science & medicine, vol 7, iss 1 |
| ISSN: | 2053-8790 |
| Popis: | BackgroundPositive remodelling index and presence of low-attenuation non-calcified plaque (LANCP) are characteristic vessel changes in unstable coronary plaques. We sought to characterise these high-risk plaque features in patients with systemic lupus erythematosus (SLE) and to compare them with controls.MethodsA total of 72 patients who satisfied the SLICC classification criteria for SLE had coronary CT angiography (CCTA) studies, 30 of which had follow-up CCTA, as screening for occult coronary atherosclerotic disease in asymptomatic individuals. A total of 100 consecutive controls with no known history of lupus, heart disease or revascularisation who had two coronary CT angiograms at least 1 year apart were included in the study. These were asymptomatic patients referred by their primary physicians for screening of coronary artery disease and the screening interval was decided by the primary physicians. The methodology for image acquisition was identical.ResultsLANCP burden at baseline was significantly greater in patients with SLE compared with controls. LANCP volume was significantly greater in patients over 60 years of age (p10 mg/day. LANCP burden remained stable over follow-up. There were no significant differences in remodelling index compared with controls.ConclusionThis is the first study describing high-risk CCTA features of coronary plaque in patients with SLE. Both LANCP and positive remodelling are common in SLE. These characteristic vessel changes may identify patients with SLE at increased risk of cardiovascular events and those in need for more frequent cardiac monitoring. |
| Databáze: | OpenAIRE |
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