Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide-, lenalidomide-, or bortezomib-containing regimens
| Autor: | Kumar, S, Giralt, S, Stadtmauer, Ea, Harousseau, Jl, Palumbo, Antonio, Bensinger, W, Comenzo, Rl, Lentzsch, S, Munshi, N, Niesvizky, R, San Miguel, J, Ludwig, H, Bergsagel, L, Blade, J, Lonial, S, Anderson, Kc, Tosi, P, Sonneveld, P, Sezer, O, Vesole, D, Cavo, M, Einsele, H, Richardson, Pg, Durie, Bg, Rajkumar, Sv, International Myeloma Working Group |
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| Přispěvatelé: | Radiology & Nuclear Medicine, Hematology, Kumar S, Giralt S, Stadtmauer EA, Harousseau JL, Palumbo A, Bensinger W, Comenzo RL, Lentzsch S, Munshi N, Niesvizky R, San Miguel J, Ludwig H, Bergsagel L, Blade J, Lonial S, Anderson KC, Tosi P, Sonneveld P, Sezer O, Vesole D, Cavo M, Einsele H, Richardson PG, Durie BG, Rajkumar SV, International Myeloma Working Group. |
| Rok vydání: | 2009 |
| Předmět: |
Oncology
medicine.medical_specialty Consensus Development Conferences as Topic medicine.medical_treatment Immunology Antineoplastic Agents Hematopoietic stem cell transplantation Medical Oncology Biochemistry Bortezomib Autologous stem-cell transplantation Internal medicine medicine Humans Lenalidomide Multiple myeloma Hematopoietic Stem Cell Mobilization Clinical Trials as Topic business.industry Hematopoietic Stem Cell Transplantation Cell Biology Hematology medicine.disease Boronic Acids Combined Modality Therapy Thalidomide Pyrazines Stem cell Multiple Myeloma business Immunosuppressive Agents medicine.drug |
| Zdroj: | Blood, 114(9), 1729-1735. American Society of Hematology |
| ISSN: | 0006-4971 |
| Popis: | The past decade has witnessed a paradigm shift in the initial treatment of multiple myeloma with the introduction of novel agents such as thalidomide, lenalidomide, and bortezomib, leading to improved outcomes. High-dose therapy and autologous stem cell transplantation remains an important therapeutic option for patients with multiple myeloma eligible for the procedure. Before the advent of the novel agents, patients underwent stem cell collection prior to significant alkylating agent exposure, given its potential deleterious effect on stem cell collection. With increasing use of the novel agents in the upfront setting, several reports have emerged raising concerns about their impact on the ability to collect stem cells. An expert panel of the International Myeloma Working Group (IMWG) was convened to examine the implications of these therapies on stem collection in patients with myeloma and to develop recommendations for addressing these issues. Here we summarize the currently available data and present our perspective on the problem and potential options to overcome this problem. Specifically, we recommend early mobilization of stem cells, preferably within the first 4 cycles of initial therapy, in patients treated with novel agents and encourage participation in clinical trials evaluating novel approaches to stem cell mobilization. (Blood. 2009;114:1729-1735) |
| Databáze: | OpenAIRE |
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