Quantitative spectral electroencephalography in predicting survival in patients with early Alzheimer disease
| Autor: | W.A. van Gool, B. Verbeeten, A. Hijdra, B.W. Ongerboer de Visser, G. J. M. Walstra, J. J. Claus |
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| Přispěvatelé: | Other departments |
| Jazyk: | angličtina |
| Rok vydání: | 1998 |
| Předmět: |
Male
Risk medicine.medical_specialty Context (language use) Electroencephalography Arts and Humanities (miscellaneous) Alzheimer Disease Predictive Value of Tests Internal medicine medicine Humans Dementia Prospective Studies Prospective cohort study Aged Proportional Hazards Models medicine.diagnostic_test Proportional hazards model Hazard ratio Memory clinic medicine.disease Survival Analysis Confidence interval Surgery Female Neurology (clinical) Psychology Follow-Up Studies |
| Zdroj: | Archives of neurology, 55(8), 1105-1111. American Medical Association |
| ISSN: | 0003-9942 |
| DOI: | 10.1001/archneur.55.8.1105 |
| Popis: | OBJECTIVE: To determine whether measures of quantitative spectral electroencephalography (EEG) can predict survival in patients with early Alzheimer disease. DESIGN: Prospective cohort study; median duration of follow-up was 4.4 years in survivors and 2.6 years in nonsurvivors. Cox proportional hazards models, with adjustment for age and sex were used to estimate relationships between EEG measures and survival. Log relative percentage values of EEG bands were used as predictors. SETTING: Outpatient university memory clinic. PARTICIPANTS: One hundred one consecutively referred patients with early probable Alzheimer disease according to National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer's Disease and Related Disorders Association criteria were studied with EEG at the time of diagnosis. The mean age of the patients was 79.2 years, which was higher than in previous EEG studies. MAIN OUTCOME MEASURE: Mortality. RESULTS: Fifty-one patients (50.5%) died during follow-up, with a median survival time in all patients of 4.1 years. The following EEG variables were significantly associated with increased risk of mortality: from parieto-occipital leads, higher theta (hazard ratio, 2.05; 95% confidence interval, 1.15-3.66; P |
| Databáze: | OpenAIRE |
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