Clinical valuables related to resolution of complete or advanced atrioventricular block after steroid therapy in patients with cardiac sarcoidosis
| Autor: | Mayu Yazaki, Shunsuke Ishii, Takeru Nabeta, Masahiko Hara, Kenji Maemura, Takumi Oki, Yuki Ikeda, Toshimi Koitabashi, Junya Ako, Teppei Fujita, Takashi Naruke |
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| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Ejection fraction business.industry Proportional hazards model Hazard ratio Area under the curve Original Articles Cardiac sarcoidosis medicine.disease cardiac sarcoidosis Confidence interval immunosuppression therapy inflammation RC666-701 Internal medicine atrioventricular block medicine Cardiology Diseases of the circulatory (Cardiovascular) system Original Article In patient Cardiology and Cardiovascular Medicine business Atrioventricular block |
| Zdroj: | Journal of Arrhythmia Journal of Arrhythmia, Vol 37, Iss 4, Pp 1093-1100 (2021) |
| ISSN: | 1883-2148 1880-4276 |
| DOI: | 10.1002/joa3.12583 |
| Popis: | Background Prediction of atrioventricular block (AVB) resolution after steroid therapy in patients with cardiac sarcoidosis (CS) is difficult. Methods We identified 24 patients with CS and complete or advanced AVB receiving steroid therapy. AVB resolution was assessed by reviewing surface electrocardiogram and the percentage of ventricular pacing required on subsequent device interrogation reports. Results AVB resolution was noted in eight (33%) patients 1 year after receiving steroid therapy. Univariate Cox regression analysis demonstrated that left ventricular ejection fraction (LVEF) (hazard ratio [HR] 1.07, 95% confidence interval [CI] 1.01‐1.14, P = .016), interval from recognized AVB to start of steroid therapy (HR 0.98, 95% CI 0.95‐0.99, P Resolution of AVB was observed in 33% patients with CS and AVB after steroid therapy. Univariate analysis demonstrated that a shorter interval from recognition of AVB to start of steroid therapy, higher LVEF, higher lysozyme levels were significantly associated with resolution of AVB after steroid therapy. The combination of each variable associated with resolution of AVB could be able to distinguish patients with resolution of AVB from those without. |
| Databáze: | OpenAIRE |
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