Cocaine users with comorbid Cluster B personality disorders show dysfunctional brain activation and connectivity in the emotional regulation networks during negative emotion maintenance and reappraisal
| Autor: | José Miguel Martínez-González, Natalia Albein-Urios, Antonio Verdejo-García, Carles Soriano-Mas, Juan Verdejo-Román, Samuel Asensio |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male Personality Inventory Emotions Statistics as Topic Impulsivity Personality Disorders Cocaine dependence Cocaine-Related Disorders Judgment medicine Image Processing Computer-Assisted Humans Pharmacology (medical) Borderline personality disorder Biological Psychiatry Anterior cingulate cortex Pharmacology Analysis of Variance Brain Mapping medicine.diagnostic_test Cluster B personality disorders Brain medicine.disease Personality disorders Magnetic Resonance Imaging Oxygen Psychiatry and Mental health medicine.anatomical_structure Neurology Orbitofrontal cortex Female Neurology (clinical) medicine.symptom Psychology Functional magnetic resonance imaging Clinical psychology |
| Zdroj: | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 23(12) |
| ISSN: | 1873-7862 |
| Popis: | Cocaine dependence often co-occurs with Cluster B personality disorders. Since both disorders are characterized by emotion regulation deficits, we predicted that cocaine comorbid patients would exhibit dysfunctional patterns of brain activation and connectivity during reappraisal of negative emotions. We recruited 18 cocaine users with comorbid Cluster B personality disorders, 17 cocaine users without comorbidities and 21 controls to be scanned using functional magnetic resonance imaging (fMRI) during performance on a reappraisal task in which they had to maintain or suppress the emotions induced by negative affective stimuli. We followed region of interest (ROI) and whole-brain approaches to investigate brain activations and connectivity associated with negative emotion experience and reappraisal. Results showed that cocaine users with comorbid personality disorders had reduced activation of the subgenual anterior cingulate cortex during negative emotion maintenance and increased activation of the lateral orbitofrontal cortex and the amygdala during reappraisal. Amygdala activation correlated with impulsivity and antisocial beliefs in the comorbid group. Connectivity analyses showed that in the cocaine comorbid group the subgenual cingulate was less efficiently connected with the amygdala and the fusiform gyri and more efficiently connected with the anterior insula during maintenance, whereas during reappraisal the left orbitofrontal cortex was more efficiently connected with the amygdala and the right orbitofrontal cortex was less efficiently connected with the dorsal striatum. We conclude that cocaine users with comorbid Cluster B personality disorders have distinctive patterns of brain activation and connectivity during maintenance and reappraisal of negative emotions, which correlate with impulsivity and dysfunctional beliefs. |
| Databáze: | OpenAIRE |
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