The importance of Notch signaling in peripheral T-cell lymphomas
| Autor: | E. Ralfkiaer, Omid Niazi, Maria R. Kamstrup, Edyta Biskup, Robert Gniadecki, Lise Mette Rahbek Gjerdrum |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Cancer Research Pathology medicine.medical_specialty Adolescent T cell Notch signaling pathway Peripheral T-cell lymphoma not otherwise specified Apoptosis Primary cutaneous anaplastic large cell lymphoma Biology Young Adult Cell Line Tumor hemic and lymphatic diseases medicine Humans Cytotoxic T cell Receptor Notch1 Child Aged Aged 80 and over Receptors Notch Oncogene Lymphoma T-Cell Peripheral Cell Cycle Checkpoints Hematology Middle Aged medicine.disease medicine.anatomical_structure Oncology Child Preschool embryonic structures Cancer research Immunohistochemistry Female Amyloid Precursor Protein Secretases Oligopeptides Signal Transduction |
| Zdroj: | Leukemia & Lymphoma. 55:639-644 |
| ISSN: | 1029-2403 1042-8194 |
| DOI: | 10.3109/10428194.2013.807510 |
| Popis: | Peripheral T-cell lymphomas (PTLs) represent an area of high medical need. Previously, we demonstrated high expression of Notch, a known oncogene, in primary cutaneous anaplastic large cell lymphoma (ALCL). In this study, we performed immunohistochemical staining for Notch1 in lymph nodes from PTL not otherwise specified (PTL-NOS) and systemic ALCL (ALK+ and ALK−) and report a similar distribution among the three subgroups: Negative, moderate and strong expression was, respectively, 18%, 27% and 55% for PTL-NOS (33 cases), 20%, 0% and 80% for ALCL ALK+ (10 cases) and 45%, 22% and 33% for ALCL ALK− (nine cases) (p > 0.05). In the ALK+ ALCL cell line, Karpas-299, pharmacological inhibition of Notch with γ-secretase inhibitor (GSI) I was far more potent than with GSI IX, XX and XXI with regard to cell viability and apoptosis. In conclusion, PTL tumor cells have prominent Notch1 expression and treatment with Notch inhibitors has cytotoxic effects. |
| Databáze: | OpenAIRE |
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