Mesenchymal Stem Cells and Inflammatory Cardiomyopathy: Cardiac Homing and Beyond
| Autor: | Carsten Tschöpe, S Van Linthout, Heinz P. Schultheiss, Ch. Stamm |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Cardiac function curve
lcsh:Diseases of the circulatory (Cardiovascular) system business.industry Mesenchymal stem cell Cardiomyopathy Inflammation Review Article medicine.disease Myocardial function lcsh:RC666-701 Heart failure Cancer research medicine medicine.symptom Stem cell Cardiology and Cardiovascular Medicine business Homing (hematopoietic) |
| Zdroj: | Cardiology Research and Practice Cardiology Research and Practice, Vol 2011 (2011) |
| ISSN: | 2090-0597 |
| DOI: | 10.4061/2011/757154 |
| Popis: | Under conventional heart failure therapy, inflammatory cardiomyopathy usually has a progressive course, merging for alternative interventional strategies. There is accumulating support for the application of cellular transplantation as a strategy to improve myocardial function. Mesenchymal stem cells (MSCs) have the advantage over other stem cells that they possess immunomodulatory features, making them attractive candidates for the treatment of inflammatory cardiomyopathy. Studies in experimental models of inflammatory cardiomyopathy have consistently demonstrated the potential of MSCs to reduce cardiac injury and to improve cardiac function. This paper gives an overview about how inflammation triggers the functionality of MSCs and how it induces cardiac homing. Finally, the potential of intravenous application of MSCs by inflammatory cardiomyopathy is discussed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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