Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas
| Autor: | Huibert D. Mansvelder, J. Russel Keath, Daniel S. McGehee |
|---|---|
| Přispěvatelé: | Integrative Neurophysiology |
| Jazyk: | angličtina |
| Rok vydání: | 2002 |
| Předmět: |
Atropine
Insecticides Patch-Clamp Techniques Dopamine Action Potentials Receptors Nicotinic Synaptic Transmission Cholinergic Antagonists Rats Sprague-Dawley Nicotine Mice 0302 clinical medicine gamma-Aminobutyric Acid Neurons 0303 health sciences Chemistry General Neuroscience Smoking Ganglionic Stimulants Electrophysiology Nicotinic agonist medicine.anatomical_structure Acetylcholinesterase GABAergic Brain stimulation reward medicine.drug medicine.medical_specialty Adolescent Neuroscience(all) Glutamic Acid Muscarinic Antagonists In Vitro Techniques Neurotransmission 03 medical and health sciences Glutamatergic Reward Quinoxalines Internal medicine medicine Animals Humans 030304 developmental biology Ventral Tegmental Area Organothiophosphorus Compounds Rats Endocrinology nervous system Cholinesterase Inhibitors Neuron Excitatory Amino Acid Antagonists Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neuron, 33(6), 905-919. Cell Press Mansvelder, H D, Keath, J R & McGehee, D S 2002, ' Synaptic mechanisms underlie nicotine-induced excitability of brain reward areas ', Neuron, vol. 33, no. 6, pp. 905-919 . https://doi.org/10.1016/S0896-6273(02)00625-6 |
| ISSN: | 0896-6273 |
| DOI: | 10.1016/S0896-6273(02)00625-6 |
| Popis: | A single nicotine exposure increases dopamine levels in the mesolimbic reward system for hours, but nicotine concentrations experienced by smokers desensitize nAChRs on dopamine neurons in seconds to minutes. Here, we show that persistent modulation of both GABAergic and glutamatergic synaptic transmission by nicotine can contribute to the sustained increase in dopamine neuron excitability. Nicotine enhances GABAergic transmission transiently, which is followed by a persistent depression of these inhibitory inputs due to nAChR desensitization. Simultaneously, nicotine enhances glutamatergic transmission through nAChRs that desensitize less than those on GABA neurons. The net effect is a shift toward excitation of the dopamine reward system. These results suggest that spatial and temporal differences in nicotinic receptor activity on both excitatory and inhibitory neurons in reward areas coordinate to reinforce nicotine self-administration. |
| Databáze: | OpenAIRE |
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