Skin Ceramide Profile in Children With Atopic Dermatitis
| Autor: | Zhi-Xin Jia, Jinlan Zhang, Lin Ma, Lei Jiao, Mutong Zhao, Chun-Ping Shen |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
Male 0301 basic medicine Ceramide Adolescent Dermatology Ceramides Severity of Illness Index Mass Spectrometry Dermatitis Atopic Young Adult 030207 dermatology & venereal diseases 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Disease severity Severity of illness medicine Stratum corneum Humans Immunology and Allergy Young adult Child Chromatography High Pressure Liquid Barrier function Aged Skin integumentary system business.industry Atopic dermatitis Middle Aged Control subjects medicine.disease carbohydrates (lipids) 030104 developmental biology medicine.anatomical_structure chemistry Immunology Female lipids (amino acids peptides and proteins) business |
| Zdroj: | Dermatitis. 29:219-222 |
| ISSN: | 2162-5220 1710-3568 |
| DOI: | 10.1097/der.0000000000000392 |
| Popis: | Background Atopic dermatitis (AD) is a common disease, which involves a disruption of the skin barrier function. Skin ceramide (CER) composition, which plays crucial roles in maintaining the barrier function of the stratum corneum, is changed in patients with AD. Objective The aim of this study was to identify and quantify skin CER subclasses in association with disease severity in pediatric patients with AD. Methods Two hundred thirteen patients were entered into the observational study. We compared their CER profiles using normal-phase high-performance liquid chromatography coupled with dynamic multiple reaction monitoring mass spectrometry. Results In total, 12 subclasses of CERs were identified. We found that 2 subclasses, that is, CER[AS] and CER[NS], were elevated (P = 0.007 and 0.012, respectively) and correlated with Severity Scoring of Atopic Dermatitis (P = 0.004 and 0.004, respectively). Conclusions Skin CER abundances are changed in children with AD compared with control subjects. |
| Databáze: | OpenAIRE |
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