Ceftriaxone (Rocephin) in Abdominal Trauma
| Autor: | V. Warren, L. C. J. Van Rensburg, R. Muller, B. L. Warren |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors Adolescent medicine.drug_class Premedication Antibiotics Wounds Penetrating Abdominal Injuries Critical Care and Intensive Care Medicine Sepsis Preoperative Care Humans Medicine Prospective Studies Prospective cohort study Aged business.industry Ceftriaxone Middle Aged medicine.disease Surgery Metronidazole medicine.anatomical_structure Abdominal trauma Anesthesia Wound Infection Abdomen business medicine.drug |
| Zdroj: | The Journal of Trauma: Injury, Infection, and Critical Care. 31:1490-1494 |
| ISSN: | 0022-5282 |
| Popis: | A prospective study was undertaken to evaluate the use of ceftriaxone in patients with abdominal trauma admitted to our hospital over a period of 6 months. Because of the large trauma load and an unacceptable waiting period before surgery combined with the fact that many patients on 6-hourly antibiotic regimes often did not receive their second and third doses, it was decided to use ceftriaxone because of its long half-life with maintenance of fluid and tissue concentrations for 24-48 hours. Because ceftriaxone is not reliably effective against anaerobic organisms such as Bacteroides fragilis, it was decided to add metronidazole as a combined initial dose. Two hundred ninety patients were entered in this trial, of which there were 259 stab wounds (89.3%), 20 missile injuries (6.9%), and 11 blunt injuries (3.8%). It was found that the mean delay between injury and initial dosage of ceftriaxone was 9.1 hours, with a range of 1-126 hours, and the mean delay between antibiotic therapy and operation 6.3 hours, with a range of 0-39 hours. The organs most frequently injured were the small bowel, the large bowel, the stomach, and the liver. Wound infection developed in only 4 patients (1.4%); intra-abdominal sepsis did not occur; and 35 patients (12%) developed respiratory infections. There were no deaths. We conclude that ceftriaxone, because of its 24-hour dosage was not only convenient but also adequate to prevent intra-abdominal sepsis and there was no difference in cost between this product and our previous protocol of 6-hourly antibiotic regime. |
| Databáze: | OpenAIRE |
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