Evaluation of the ultrastructural and in vitro flow properties of the PRESERFLO MicroShunt
| Autor: | Laura Morales Fernández, Jean Bragard, Marta Ibarz Barberá, Pedro Tañá Rivero, Javier Burguete, José Luis Hernández-Verdejo, Rosario Gómez de Liaño, Miguel A. Teus |
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| Rok vydání: | 2021 |
| Předmět: |
Intraocular pressure
Materials science Scanning electron microscope Biomedical Engineering Glaucoma Hagen-Poiseuille Article Aqueous Humor Viscosity Tonometry Ocular Glaucoma surgery Cirugía medicine Fluid dynamics Materiales ópticos aqueous flow Glaucoma Drainage Implants Pressure drop Óptica y optometría Intraocular Pressure pressure drop medicine.disease Ophthalmology Flow (mathematics) glaucoma surgery Aqueous flow Ultrastructure Oftalmología PRESERFLO Biomedical engineering |
| Zdroj: | Dadun. Depósito Académico Digital de la Universidad de Navarra instname Translational Vision Science & Technology E-Prints Complutense. Archivo Institucional de la UCM Universidad Europea (UEM) |
| Popis: | Purpose: To measure the in vitro flow properties of the PRESERFLO implant for comparison with the theoretical resistance to flow. Methods: The PRESERFLO was designed to control the flow of aqueous humor according to the Hagen-Poiseuille (HP) equation. Scanning electron microscopy (SEM) was performed to analyze the ultrastructure, and flow measurements were carried out using a gravity-flow setup. Results: SEM images of the PRESERFLO showed luminal diameters of 67.73 x 65.95 mu m and 63.66 x 70.54 mu m. The total diameter was 337.2 mu m, and the wall was 154 mu m wide. The theoretical calculation of the resistance to flow (R) for an aqueous humor (AH) viscosity of 0.7185 centipoises (cP) was 1.3 mm Hg/(mu L/min). Hence, assuming a constant AH flow of 2 mu L/min, the pressure differential across the device (AP) was estimated to be 2.6 mm Hg. The gravity-flow experiment allowed us to measure the experimental resistance to flow, which was R-E = 1.301 mm Hg/(mu L/min), in agreement with the theoretical resistance to flow R given by the HP equation. Conclusions: The experimental and theoretical flow testing showed that the pressure drop across this device would not be large enough to avoid hypotony unless the resistance to outflow of the sub-Tenon space was sufficient to control the intraocular pressure in the early postoperative period. Translational Relevance: The fluid properties of glaucoma subconjunctival drainage devices determine their specific bleb-forming capacity and ability to avoid hypotony and therefore their safety and efficacy profile. Translational Relevance: The fluid properties of glaucoma subconjunctival drainage devices determine their specific bleb-forming capacity and ability to avoid hypotony and therefore their safety and efficacy profile. |
| Databáze: | OpenAIRE |
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