Imaging of cardiac and renal perfusion in a rat model with 13N–NH3 micro-PET
| Autor: | Erick Alexanderson, René A. Tio, Luis Eduardo Juarez-Orozco, Rudi Dierckx, Hans L. Hillege, Mariusz K. Szymanski, Silvana Kruizinga, Michel Koole, Riemer H. J. A. Slart, Walter Noordzij |
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| Přispěvatelé: | Life Course Epidemiology (LCE), Cardiovascular Centre (CVC), Groningen Kidney Center (GKC), Vascular Ageing Programme (VAP), Molecular Neuroscience and Ageing Research (MOLAR), Translational Immunology Groningen (TRIGR), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE) |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Myocardial Infarction Perfusion scanning Renal Circulation POSITRON-EMISSION-TOMOGRAPHY Ammonia Predictive Value of Tests LEFT-VENTRICULAR FUNCTION Coronary Circulation Internal medicine medicine Animals Radiology Nuclear Medicine and imaging Myocardial infarction Rats Wistar Cardiac imaging Ejection fraction BLOOD-FLOW medicine.diagnostic_test business.industry Myocardium Cardiorenal Myocardial Perfusion Imaging Sham surgery Stroke Volume N-13-ammonia Blood flow QUANTIFICATION medicine.disease CHRONIC HEART-FAILURE Perfusion Disease Models Animal PET Positron emission tomography Positron-Emission Tomography Cardiology Radiopharmaceuticals Cardiology and Cardiovascular Medicine business |
| Zdroj: | International Journal Of Cardiovascular Imaging, 31(1), 213-219. SPRINGER |
| ISSN: | 1573-0743 1569-5794 |
| Popis: | Cardiac dysfunction leads to decreased organ perfusion. We aimed to measure cardiac and renal perfusion simultaneously with the use of N-13-NH3-microPET in different rat models. Ten male Wistar rats underwent sham surgery (n = 5) or permanent coronary artery ligation to induce myocardial infarction (MI, n = 5). Eleven weeks later N-13-NH3-microPET scan was performed to study the cardiac and renal perfusion. Cardiac perfusion was significantly reduced in MI group, directly correlated with ejection fraction and inversely correlated with MI size (r = 0.89; p |
| Databáze: | OpenAIRE |
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